|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:p38_MAP_kinase
|
|
gptkbp:alias
|
gptkb:MAPKAP_kinase_2
gptkb:MAP_kinase-activated_protein_kinase_2
MK2
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
|
|
gptkbp:discoveredBy
|
G. Stöcklin et al.
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000127914
9261
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Mitogen-activated_protein_kinase-activated_protein_kinase_2
|
|
gptkbp:function
|
serine/threonine-protein kinase
regulates stress and inflammatory responses
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6882
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAPKAPK2
|
|
gptkbp:inhibitedBy
|
gptkb:CMPD1
gptkb:MK2_Inhibitor_III
gptkb:PF-3644022
|
|
gptkbp:involvedIn
|
regulation of gene expression
inflammatory response
cellular response to stress
|
|
gptkbp:length
|
400
|
|
gptkbp:locatedOnChromosome
|
1
|
|
gptkbp:location
|
1q32.1
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:PDB
|
gptkb:2OZA
gptkb:3KNB
4QTB
|
|
gptkbp:phosphorylates
|
gptkb:CREB
gptkb:HSP27
gptkb:SRF
gptkb:TTP
|
|
gptkbp:regulates
|
apoptosis
cell migration
cell cycle
cytokine production
mRNA stability
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P49137
|
|
gptkbp:bfsParent
|
gptkb:p38_MAPK_pathway
|
|
gptkbp:bfsLayer
|
6
|