Statements (532)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:cancer
gptkb:disease gptkb:organization medical condition Malignant tumor malignant tumor |
| gptkbp:abbreviation |
gptkb:SCC
|
| gptkbp:affects |
gptkb:cervix
gptkb:endometrium gptkb:skin lungs vagina esophagus thyroid gland uterus mouth vulva throat any part of the body anus |
| gptkbp:affectsOrgan |
gptkb:Thyroid_gland
gptkb:breast gptkb:cervix gptkb:endometrium gptkb:Vulva gptkb:cancer gptkb:skin gptkb:kidney gptkb:prostate gptkb:small_intestine gptkb:testis gptkb:Anus gptkb:Head_and_Neck Mouth vagina liver Lungs Liver Stomach bladder colon esophagus pancreas salivary gland stomach uterus Bile duct Bladder Breast Cervix Colon Endometrium Esophagus Gallbladder Kidney Lung Ovary Pancreas Prostate Salivary gland Small intestine Thyroid Throat Oral cavity Vagina Epithelial tissue bile duct |
| gptkbp:age |
Most common in adults aged 30-60
|
| gptkbp:alternativeName |
gptkb:cancer
Adenocarcinoma Cancer Cancer_support_centre Comprehensive_Cancer_Center Kanker Lung_Cancer Squamous_Cell_Carcinoma Squamous_cell_carcinoma Thyroid_cancer adenocarcinoma breast_cancer cancer_center cancer_hospital cancer_research_center cancer_research_centre cancer_research_institute cancer_research_organization cancer_researcher cancer_support_centre cancer_survivor cancer_therapy cancer_treatment cancer_treatment_center carcinogen carcinoma cervical_cancer clear_cell_carcinoma comprehensive_cancer_center endometrial_carcinoma endometrioid_carcinoma lung lung_cancer lung_disease malignant_neoplasm ovarian_cancer skin_cancer squamous_cell_carcinoma thyroid_cancer |
| gptkbp:annualIncidenceWorldwide |
over 500,000 cases
|
| gptkbp:associatedWith |
gptkb:RAS
gptkb:cancer gptkb:pneumonia gptkb:RET gptkb:RAS_gene gptkb:RET_proto-oncogene gptkb:BRAF gptkb:BRAF_gene gptkb:polycystic_ovary_syndrome asthma tuberculosis obesity chronic obstructive pulmonary disease estrogen exposure endometrial hyperplasia |
| gptkbp:bloodSupply |
gptkb:pulmonary_vein
pulmonary artery |
| gptkbp:canBeMalignant |
True
true |
| gptkbp:canBeSporadic |
Yes
yes |
| gptkbp:canMetastasizeTo |
gptkb:bone
gptkb:Bones brain true lungs liver Lungs Liver lymph nodes bones adrenal glands Lymph nodes peritoneum distant organs |
| gptkbp:cause |
gptkb:Hyperthyroidism
Hypothyroidism hyperthyroidism (rarely) hypothyroidism after treatment |
| gptkbp:causedBy |
radiation exposure
environmental factors genetic mutations tobacco use certain infections |
| gptkbp:characteristic |
cells with clear cytoplasm
|
| gptkbp:collaboratesWith |
other research institutions
|
| gptkbp:color |
gray-black (smoker)
pink (healthy) |
| gptkbp:commonIn |
gptkb:women
Adults Children older adults Women Older adults males postmenopausal women adults aged 30-60 premenopausal women |
| gptkbp:designation |
gptkb:National_Cancer_Institute
|
| gptkbp:detects |
thyroglobulin test
|
| gptkbp:develops_from |
squamous cells
|
| gptkbp:diagnosedBy |
gptkb:chest_X-ray
gptkb:CT_scan imaging MRI ultrasound biopsy blood tests Imaging Biopsy Histopathology Ultrasound histopathology Blood tests Fine-needle aspiration biopsy imaging tests dilation and curettage endometrial biopsy fine-needle aspiration biopsy transvaginal ultrasound |
| gptkbp:differentialDiagnosis |
gptkb:cancer
gptkb:serous_carcinoma mucinous carcinoma |
| gptkbp:explores |
pulmonologist
stethoscope |
| gptkbp:firstDescribed |
gptkb:Sir_Jonathan_Hutchinson
18th century 19th century 20th century Galen |
| gptkbp:firstDesignated |
1971
|
| gptkbp:focusesOn |
gptkb:cancer
cancer prevention cancer research cancer education |
| gptkbp:followedBy |
Regular neck ultrasound
Thyroglobulin blood test |
| gptkbp:followUpRequired |
yes
|
| gptkbp:function |
gas exchange
removes carbon dioxide from blood oxygenates blood |
| gptkbp:fundedBy |
gptkb:National_Cancer_Institute
|
| gptkbp:grades |
graded by degree of glandular differentiation
|
| gptkbp:hasAwarenessMonth |
October (Breast Cancer)
|
| gptkbp:hasDiagnosticMethod |
Imaging
Biopsy Histopathology |
| gptkbp:hasGeneticAlteration |
gptkb:ALK_rearrangement
gptkb:EGFR_mutation gptkb:KRAS_mutation |
| gptkbp:hasImagingFinding |
heterogeneous enhancement
solid or cystic mass |
| gptkbp:hasLanguage |
gptkb:Indonesian
|
| gptkbp:hasMembrane |
gptkb:pleura
|
| gptkbp:hasPart |
gptkb:bronchioles
gptkb:pleura capillaries alveoli bronchi |
| gptkbp:hasScreeningTest |
gptkb:low-dose_CT_scan
|
| gptkbp:hasSurvivalRate |
5-year survival rate less than 20%
|
| gptkbp:hasType |
gptkb:non-small_cell_lung_cancer
gptkb:anaplastic_thyroid_cancer gptkb:cancer gptkb:rhabdomyosarcoma leukemia melanoma Small Cell Lung Cancer epithelial cell follicular thyroid cancer medullary thyroid cancer papillary thyroid cancer clear cell |
| gptkbp:hereditary |
Yes
yes |
| gptkbp:histology |
gptkb:cancer
glycogen-rich clear cytoplasm |
| https://www.w3.org/2000/01/rdf-schema#label |
cancer
|
| gptkbp:ICD-10_code |
gptkb:C73
gptkb:C34_(lung) gptkb:C54.1 gptkb:C54_(endometrial) gptkb:C64_(renal) C80.1 C34 C00-D49 C44 C56 (ovarian) C44.2 |
| gptkbp:incidence |
Incidence increasing worldwide
More common in women over 2 million cases per year |
| gptkbp:innervates |
gptkb:vagus_nerve
gptkb:phrenic_nerve |
| gptkbp:isCommonSkinCancerType |
True
|
| gptkbp:isLessCommonIn |
premenopausal women
|
| gptkbp:isMoreCommonIn |
postmenopausal women
|
| gptkbp:isMostCommonGynecologicCancerIn |
developed countries
|
| gptkbp:isScreenedBy |
not routinely screened
|
| gptkbp:isSecondMostCommonSkinCancer |
True
|
| gptkbp:isStagedBy |
gptkb:FIGO_system
|
| gptkbp:leadingCauseOf |
cancer death worldwide
|
| gptkbp:leftLungLobes |
2
|
| gptkbp:locatedIn |
gptkb:United_States
|
| gptkbp:location |
thoracic cavity
|
| gptkbp:mainCellType |
alveolar macrophage
endothelial cell pneumocyte |
| gptkbp:mainFunction |
respiration
|
| gptkbp:marking |
gptkb:Calcitonin
gptkb:Thyroglobulin gptkb:CEA gptkb:EMA gptkb:CK7 gptkb:Napsin_A gptkb:HNF-1β gptkb:PAX8 |
| gptkbp:medianAge |
60 years
|
| gptkbp:meetsCriteriaOf |
NCI standards for research, treatment, and education
|
| gptkbp:MeSH_ID |
D000230
D018310 |
| gptkbp:monitors |
imaging studies
follow-up pelvic exams |
| gptkbp:morphologicalType |
resembles endometrial glands
|
| gptkbp:mortalityRate |
Low for most types
low for most types high for some types over 1.7 million deaths per year |
| gptkbp:mutationAssociatedWith |
gptkb:KRAS
gptkb:CTNNB1 gptkb:ARID1A gptkb:PIK3CA gptkb:PTEN gptkb:MSI_(microsatellite_instability) |
| gptkbp:numberInHumanBody |
2
|
| gptkbp:numberInUS |
over 50
|
| gptkbp:OMIM |
615010
|
| gptkbp:originatedIn |
Glandular epithelial cells
glandular tissue ovarian tissue Squamous cell endometrial tissue Squamous epithelial cells |
| gptkbp:partOf |
respiratory system
|
| gptkbp:photographed |
gptkb:chest_X-ray
gptkb:CT_scan MRI ultrasound |
| gptkbp:plural |
lungs
|
| gptkbp:prevalence |
Rare compared to other cancers
common worldwide increasing in women higher in men rare (except in kidney) |
| gptkbp:prevention |
HPV vaccination
vaccine weight management physical activity healthy diet regular exercise smoking cessation screening Sun protection sun protection Avoiding unnecessary radiation exposure oral contraceptive use avoiding tobacco avoiding carcinogen exposure |
| gptkbp:prognosis |
gptkb:theatre
place poor variable Variable metastasis Size Generally good for most types stage at diagnosis generally good for most types generally good if detected early varies by type and stage tumor size Patient health generally favorable if detected early histologic grade Metastasis |
| gptkbp:provides |
clinical trials
community outreach patient care |
| gptkbp:rareIn |
Children
women under 40 years |
| gptkbp:rareType |
gptkb:anaplastic_thyroid_cancer
|
| gptkbp:recurrencePossible |
yes
|
| gptkbp:relatedTo |
heart
diaphragm trachea |
| gptkbp:rightLungLobes |
3
|
| gptkbp:riskFactor |
gptkb:Tobacco_use
gptkb:food gptkb:air_pollution gptkb:Lynch_syndrome gptkb:diabetes_mellitus gptkb:polycystic_ovary_syndrome age family history Smoking alcohol consumption obesity radiation exposure smoking immunosuppression hypertension genetic predisposition Obesity Alcohol consumption Chronic inflammation Diet high in red meat Family history Genetic predisposition Hormonal factors asbestos exposure Immunosuppression Genetic syndromes Radiation exposure early menarche genetic syndromes late menopause nulliparity tamoxifen use tobacco use endometriosis HPV infection exposure to carcinogens chronic inflammation radon exposure secondhand smoke Sun exposure hormonal factors sun exposure exposure to diethylstilbestrol unopposed estrogen exposure Chronic wounds family history of endometrial cancer |
| gptkbp:scientificName |
pulmo
|
| gptkbp:screeningRecommended |
Not for general population
|
| gptkbp:screeningRecommendedFor |
high-risk individuals
|
| gptkbp:stageName |
gptkb:TNM
gptkb:AJCC_system gptkb:TNM_system gptkb:FIGO_(for_gynecologic_sites) stage I stage II stage III stage IV |
| gptkbp:stagingSystem |
gptkb:FIGO
|
| gptkbp:subspecies |
gptkb:Anaplastic_thyroid_cancer
gptkb:Follicular_thyroid_cancer gptkb:Medullary_thyroid_cancer gptkb:Papillary_thyroid_cancer gptkb:cancer gptkb:Clear_cell_adenocarcinoma gptkb:Mucinous_adenocarcinoma gptkb:Papillary_adenocarcinoma gptkb:Signet_ring_cell_carcinoma gptkb:Tubular_adenocarcinoma gptkb:serous_carcinoma gptkb:endometrial_cancer gptkb:Non-melanoma_skin_cancer gptkb:signet_ring_cell_carcinoma gptkb:clear_cell_adenocarcinoma_of_the_female_genital_tract gptkb:clear_cell_carcinoma_of_the_endometrium gptkb:clear_cell_carcinoma_of_the_lung gptkb:clear_cell_ovarian_carcinoma gptkb:endometrioid_endometrial_carcinoma gptkb:endometrioid_ovarian_carcinoma gptkb:Cutaneous_Squamous_Cell_Carcinoma gptkb:Squamous_Cell_Carcinoma_of_the_Cervix gptkb:Squamous_Cell_Carcinoma_of_the_Esophagus gptkb:Squamous_Cell_Carcinoma_of_the_Head_and_Neck gptkb:Squamous_Cell_Carcinoma_of_the_Lung Bronchioloalveolar carcinoma Carcinoma clear cell renal cell carcinoma acinar adenocarcinoma bronchioloalveolar carcinoma clear cell adenocarcinoma cribriform adenocarcinoma mucinous adenocarcinoma papillary adenocarcinoma tubular adenocarcinoma |
| gptkbp:surface |
about 70 square meters
|
| gptkbp:symbol |
pink ribbon (Breast Cancer)
|
| gptkbp:symptom |
gptkb:Pain
pain bleeding fatigue jaundice weight loss Weight loss cough difficulty swallowing shortness of breath lump chest pain Fatigue unexplained weight loss hoarseness Bleeding Obstruction Difficulty swallowing Hoarseness Neck lump abnormal uterine bleeding neck lump pelvic pain swollen lymph nodes abdominal distension skin changes change in bowel habits skin lesion coughing up blood Non-healing ulcer Skin lesion non-healing ulcer Bleeding lesion Red nodule Scaly patch |
| gptkbp:synonym |
gptkb:SCC
gptkb:glycogen-rich_carcinoma clear cell adenocarcinoma epidermoid carcinoma |
| gptkbp:translatedInto |
cancer (English)
|
| gptkbp:treatment |
surgery
radiation therapy Surgery chemotherapy immunotherapy Chemotherapy targeted therapy Targeted therapy External beam radiation therapy Radioactive iodine therapy Thyroid hormone therapy external beam radiation therapy hormonal therapy hysterectomy radioactive iodine therapy thyroid hormone therapy gynecologic oncologist |
| gptkbp:ventilatedBy |
breathing
mechanical ventilator |
| gptkbp:volume |
about 6 liters (total capacity)
|
| gptkbp:vulnerableTo |
infection
inflammation fibrosis |
| gptkbp:website |
gptkb:testis
uterus |
| gptkbp:weightInAdultHuman |
about 1.3 kg
|
| gptkbp:bfsParent |
gptkb:Arthur_H._Compton
gptkb:Koch_Institute_for_Integrative_Cancer_Research gptkb:Norman_Borlaug gptkb:Richard_Feynman gptkb:Robert_Taylor gptkb:human |
| gptkbp:bfsLayer |
3
|