|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:C-peptide
gptkb:Insulin_chain_A
gptkb:Insulin_chain_B
gptkb:Preproinsulin
gptkb:Proinsulin
|
|
gptkbp:associatedWith
|
gptkb:Diabetes_mellitus
|
|
gptkbp:biologicalProcess
|
hormone
regulation of cell growth
glucose homeostasis
insulin receptor binding
|
|
gptkbp:cellularComponent
|
extracellular region
|
|
gptkbp:chain
|
25-54 (B chain)
90-110 (A chain)
|
|
gptkbp:disulfideBond
|
A20-B19
A6-B7
A7-B7
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000254647
3630
|
|
gptkbp:enzymeCommissionNumber
|
nan
|
|
gptkbp:function
|
Regulation of glucose homeostasis
|
|
gptkbp:gene
|
gptkb:INS
|
|
gptkbp:hasClinicalUse
|
Treatment of diabetes
|
|
gptkbp:HGNC_ID
|
6081
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P04049
|
|
gptkbp:InterPro
|
gptkb:IPR022352
|
|
gptkbp:isAllergen
|
false
|
|
gptkbp:isSecreted
|
true
|
|
gptkbp:KEGGID
|
gptkb:hsa:3630
|
|
gptkbp:locatedOnChromosome
|
11
|
|
gptkbp:mass
|
11793 Da
|
|
gptkbp:OMIM
|
176730
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:2MVC
gptkb:1TRZ
gptkb:2HIU
gptkb:4EWW
3I3Z
|
|
gptkbp:postTranslationalModification
|
Disulfide bond
Cleavage on pair of basic residues
|
|
gptkbp:propeptide
|
57-89 (C-peptide)
|
|
gptkbp:proteinFamily
|
gptkb:PF00049
|
|
gptkbp:Reactome
|
gptkb:R-HSA-264876
|
|
gptkbp:RefSeq
|
gptkb:NP_000198.1
|
|
gptkbp:reviewedBy
|
true
|
|
gptkbp:sequence
|
110
|
|
gptkbp:signalPeptide
|
1-24
|
|
gptkbp:subcellularLocation
|
Secreted
|
|
gptkbp:tissue_specificity
|
gptkb:Pancreatic_islets
|
|
gptkbp:UniProt_entry_name
|
gptkb:Insulin
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:RAFB1
gptkb:3p25_(CRAF)
gptkb:RAF1
|
|
gptkbp:bfsLayer
|
6
|