|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:B-raf_proto-oncogene
gptkb:serine/threonine-protein_kinase_B-raf
gptkb:v-raf_murine_sarcoma_viral_oncogene_homolog_B1
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
melanoma
|
|
gptkbp:discoveredBy
|
Davies et al.
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodes
|
gptkb:B-Raf_protein
|
|
gptkbp:Entrez_Gene_ID
|
673
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1097
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BRAF
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:length
|
18 exons
|
|
gptkbp:locatedIn
|
gptkb:chromosome_7
|
|
gptkbp:locatedOn
|
gptkb:7q34
|
|
gptkbp:molecularWeight
|
~84 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:V600K
oncogenic
V600E
|
|
gptkbp:OMIM
|
164757
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:protein_domains
|
gptkb:Ras-binding_domain
cysteine-rich domain
protein kinase domain
|
|
gptkbp:proteinFamily
|
gptkb:RAF_family
|
|
gptkbp:regulates
|
cell differentiation
cell survival
cell growth
|
|
gptkbp:relatedTo
|
gptkb:ARAF
gptkb:CRAF
|
|
gptkbp:reviewedBy
|
gptkb:Cancer_Cell_2002
gptkb:Nature_2002
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:target
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:cancer
|
|
gptkbp:bfsLayer
|
4
|