|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:alternativeName
|
Rat sarcoma proteins
|
|
gptkbp:associatedWith
|
gptkb:leukemia
gptkb:cancer
gptkb:melanoma
colorectal cancer
pancreatic cancer
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:encodedBy
|
gptkb:RAS_genes
|
|
gptkbp:firstDescribed
|
1960s
|
|
gptkbp:form
|
GTP-bound
|
|
gptkbp:function
|
signal transduction
|
|
gptkbp:gene
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:inactiveForm
|
GDP-bound
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:RAF_kinase
gptkb:RalGDS
gptkb:SOS_(guanine_nucleotide_exchange_factor)
|
|
gptkbp:locale
|
inner surface of plasma membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_superfamily
|
|
gptkbp:mutationAssociatedWith
|
codon 12
codon 13
codon 61
|
|
gptkbp:mutationsAssociatedWith
|
gptkb:cancer
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDBEntry
|
gptkb:5P21
4Q21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell survival
cell migration
|
|
gptkbp:structure
|
G domain
hypervariable region
|
|
gptkbp:target
|
anticancer drug development
|
|
gptkbp:bfsParent
|
gptkb:PIK3CB
gptkb:PIK3CG
gptkb:RTK-RAS_pathway
gptkb:SOS1
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS proteins
|