RAS proteins

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy guanine nucleotide exchange factors (GEFs)
gptkbp:alternativeName Rat sarcoma proteins
gptkbp:associatedWith gptkb:cancer
colorectal cancer
leukemia
melanoma
pancreatic cancer
gptkbp:binds gptkb:GDP
gptkb:GTP
gptkbp:decommissioned GTPase-activating proteins (GAPs)
gptkbp:discoveredBy gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
gptkbp:encodedBy gptkb:RAS_genes
gptkbp:firstDescribed 1960s
gptkbp:form GTP-bound
gptkbp:function signal transduction
gptkbp:gene gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
https://www.w3.org/2000/01/rdf-schema#label RAS proteins
gptkbp:inactiveForm GDP-bound
gptkbp:interactsWith gptkb:PI3K
gptkb:RAF_kinase
gptkb:RalGDS
gptkb:SOS_(guanine_nucleotide_exchange_factor)
gptkbp:locale inner surface of plasma membrane
gptkbp:locatedOnChromosome gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
gptkbp:memberOf gptkb:small_GTPase_superfamily
gptkbp:mutationAssociatedWith codon 12
codon 13
codon 61
gptkbp:mutationsAssociatedWith gptkb:cancer
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
gptkbp:PDBEntry gptkb:5P21
4Q21
gptkbp:postTranslationalModification farnesylation
palmitoylation
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
cell survival
cell migration
gptkbp:structure G domain
hypervariable region
gptkbp:target anticancer drug development
gptkbp:bfsParent gptkb:PIK3CB
gptkb:PIK3CG
gptkbp:bfsLayer 5