|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MMAC1
gptkb:TEP1
|
|
gptkbp:discoveredBy
|
gptkb:Paula_S._L._Huang
gptkb:Peter_C._Steck
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171862
5728
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.1.3.67
|
|
gptkbp:expressedIn
|
gptkb:breast
gptkb:cervix
gptkb:endometrium
gptkb:epididymis
gptkb:fallopian_tube
gptkb:gallbladder
gptkb:large_intestine
gptkb:peripheral_blood_leukocyte
gptkb:seminal_vesicle
gptkb:thyroid
gptkb:cancer
gptkb:bone
gptkb:skin
gptkb:pituitary_gland
gptkb:skeletal_muscle
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:spinal_cord
gptkb:testis
gptkb:thymus
brain
heart
retina
liver
many tissues
collagen
spleen
tonsil
adipose tissue
bladder
bone marrow
colon
esophagus
lymph node
pancreas
parathyroid gland
prostate gland
salivary gland
stomach
uterus
appendix
|
|
gptkbp:fullName
|
gptkb:phosphatase_and_tensin_homolog
|
|
gptkbp:function
|
tumor suppressor
negative regulation of PI3K/AKT pathway
phosphatase activity
regulation of apoptosis
regulation of cell cycle
|
|
gptkbp:HGNC_ID
|
9588
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTEN
|
|
gptkbp:inhibitedBy
|
oxidative stress
phosphorylation at C-terminal tail
|
|
gptkbp:interactsWith
|
gptkb:AKT1
gptkb:MAGI2
gptkb:NEDD4-1
gptkb:PTK2
gptkb:p53
PDZ domain proteins
|
|
gptkbp:length
|
403 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q23.3
10
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Bannayan–Riley–Ruvalcaba_syndrome
gptkb:cancer
gptkb:Cowden_syndrome
gptkb:endometrial_cancer
gptkb:glioblastoma
melanoma
prostate cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
ubiquitination
|
|
gptkbp:regulates
|
cell proliferation
cell survival
DNA repair
angiogenesis
cell migration
cellular metabolism
cell adhesion
|
|
gptkbp:structure
|
contains C2 domain
contains phosphatase domain
|
|
gptkbp:substrate
|
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
gptkb:protein_phosphotyrosine
|
|
gptkbp:UniProtID
|
gptkb:P60484
|
|
gptkbp:bfsParent
|
gptkb:cancer
|
|
gptkbp:bfsLayer
|
4
|