Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Cowden_syndrome
gptkb:Lhermitte-Duclos_disease tumor suppression |
| gptkbp:challenges |
leads to tumorigenesis
|
| gptkbp:code |
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
|
| gptkbp:function |
phosphatase
|
| gptkbp:genetic_studies |
associated with cancer
|
| gptkbp:has_variants |
PTEN-L
PTEN-M |
| https://www.w3.org/2000/01/rdf-schema#label |
PTEN
|
| gptkbp:initiated_by |
AKT signaling pathway
|
| gptkbp:interacts_with |
PI3 K
|
| gptkbp:involved_in |
cell cycle regulation
|
| gptkbp:is_essential_for |
normal cell growth
|
| gptkbp:is_expressed_in |
various tissues
|
| gptkbp:is_involved_in |
metabolism
DNA repair cell differentiation cellular homeostasis cellular stress response glucose metabolism immune response lipid metabolism protein synthesis signal transduction inflammation cellular proliferation cellular senescence tumor microenvironment cellular aging cellular differentiation cellular development neurogenesis angiogenesis cell adhesion cell migration metastasis cellular signaling pathways autophagy stem cell maintenance cellular signaling cellular repair mechanisms cellular apoptosis cellular stress response pathways |
| gptkbp:is_linked_to |
gptkb:Oncology
endometrial cancer |
| gptkbp:is_part_of |
PI3 K/ AKT pathway
|
| gptkbp:is_recognized_as |
gptkb:1997
|
| gptkbp:is_regulated_by |
micro RNAs
|
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_targeted_at |
therapeutic agents
|
| gptkbp:located_in |
chromosome 10
|
| gptkbp:role |
apoptosis
|
| gptkbp:bfsParent |
gptkb:Oncology
|
| gptkbp:bfsLayer |
4
|