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gptkbp:instanceOf
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gptkb:UniProt_accession_number
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gptkbp:alternativeName
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gptkb:Cellular_tumor_antigen_p53
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
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gptkbp:associatedWith
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gptkb:Li-Fraumeni_syndrome
Various cancers
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gptkbp:biologicalProcess
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DNA repair
Autophagy
Apoptosis
DNA-binding
Cell cycle arrest
Transcription factor activity
Senescence
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gptkbp:database
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gptkb:UniProt
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gptkbp:function
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Acts as a tumor suppressor in many tumor types
Induces growth arrest or apoptosis
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gptkbp:gene
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gptkb:TP53
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gptkbp:interactsWith
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gptkb:CDKN1A
gptkb:CASP8
gptkb:CASP9
gptkb:CHEK2
gptkb:CREBBP
gptkb:EP300
gptkb:HDAC10
gptkb:HDAC11
gptkb:HDAC2
gptkb:HDAC3
gptkb:HDAC4
gptkb:HDAC5
gptkb:HDAC6
gptkb:HDAC7
gptkb:HDAC8
gptkb:HDAC9
gptkb:SIRT1
gptkb:SIRT2
gptkb:SIRT3
gptkb:SIRT6
gptkb:SIRT7
gptkb:SUMO1
gptkb:SUMO2
gptkb:SUMO3
gptkb:TP53BP1
gptkb:TP53BP2
gptkb:TP53INP1
gptkb:TP53INP2
gptkb:TP53RK
gptkb:TP53TG1
gptkb:TP53TG10
gptkb:TP53TG11
gptkb:TP53TG12
gptkb:TP53TG13
gptkb:TP53TG14
gptkb:TP53TG15
gptkb:TP53TG16
gptkb:TP53TG17
gptkb:TP53TG18
gptkb:TP53TG19
gptkb:TP53TG20
gptkb:TP53TG21
gptkb:TP53TG22
gptkb:TP53TG23
gptkb:TP53TG24
gptkb:TP53TG25
gptkb:TP53TG3
gptkb:TP53TG5
gptkb:TP53TG6
gptkb:TP53TG7
gptkb:TP53TG8
gptkb:TP53TG9
gptkb:USP7
gptkb:FAS
gptkb:RB1
gptkb:BAX
gptkb:MDM2
gptkb:PTEN
gptkb:BRCA1
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
gptkb:E2F1
gptkb:HDAC1
gptkb:BCL2
gptkb:CDKN2A
gptkb:GADD45A
gptkb:MDM4
gptkb:ATM
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gptkbp:locatedOnChromosome
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17p13.1
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gptkbp:organism
|
gptkb:Homo_sapiens
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gptkbp:pathway
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Apoptosis
Cell cycle
p53 signaling pathway
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gptkbp:postTranslationalModification
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Methylation
Phosphorylation
Acetylation
Ubiquitination
Sumoylation
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gptkbp:protein_existence
|
Evidence at protein level
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gptkbp:refersTo
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gptkb:Tumor_protein_p53_(human)
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gptkbp:reviewedBy
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Yes
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gptkbp:sequence
|
393
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gptkbp:structure
|
Tetramer
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gptkbp:subcellularLocation
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gptkb:Mitochondrion
gptkb:Nucleus
gptkb:Cytoplasm
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gptkbp:bfsParent
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gptkb:SHC1
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gptkbp:bfsLayer
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7
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https://www.w3.org/2000/01/rdf-schema#label
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P29353
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