|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:cancer
multiple myeloma
neurodegenerative diseases
autoimmune diseases
|
|
gptkbp:discoveredBy
|
gptkb:Emiliani_et_al.
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:domain
|
two catalytic deacetylase domains
zinc finger ubiquitin-binding domain
|
|
gptkbp:encodedBy
|
gptkb:HDAC6_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000147099
10013
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.5.1.98
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_6
|
|
gptkbp:function
|
protein degradation
cell motility
stress response
regulation of microtubule dynamics
deacetylation of lysine residues on histone and non-histone proteins
|
|
gptkbp:gene
|
gptkb:HDAC6
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:14064
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC6
|
|
gptkbp:inhibitedBy
|
gptkb:trichostatin_A
gptkb:vorinostat
gptkb:ACY-1215_(ricolinostat)
gptkb:tubastatin_A
|
|
gptkbp:length
|
1215 amino acids
|
|
gptkbp:locatedOnChromosome
|
X
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:memberOf
|
gptkb:class_IIb_HDACs
histone deacetylase family
|
|
gptkbp:molecularWeight
|
131 kDa
|
|
gptkbp:OMIM
|
300172
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hdac6
|
|
gptkbp:orthologInZebrafish
|
hdac6
|
|
gptkbp:substrate
|
gptkb:alpha-tubulin
gptkb:cortactin
gptkb:peroxiredoxins
gptkb:Hsp90
|
|
gptkbp:UniProtID
|
gptkb:Q9UBN7
|
|
gptkbp:bfsParent
|
gptkb:vorinostat
|
|
gptkbp:bfsLayer
|
6
|