Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:Li-Fraumeni_syndrome |
| gptkbp:code |
gptkb:checkpoint_kinase_2
|
| gptkbp:discovered_by |
genetic research
|
| gptkbp:function |
tumor suppressor
|
| gptkbp:genetic_studies |
can lead to cancer predisposition
|
| gptkbp:has_role |
apoptosis
tumorigenesis |
| gptkbp:has_variants |
gptkb:CHEK2*1100del_C
gptkb:CHEK2*_I157_T CHEK2* E39 K CHEK2* IVS1+1 G> A CHEK2* Q151 X |
| https://www.w3.org/2000/01/rdf-schema#label |
CHEK2
|
| gptkbp:interacts_with |
gptkb:TP53
|
| gptkbp:involved_in |
DNA damage response
|
| gptkbp:is_associated_with |
gptkb:Oncology
gptkb:pancreatic_cancer ovarian cancer |
| gptkbp:is_essential_for |
genomic stability
|
| gptkbp:is_expressed_in |
various tissues
breast tissue prostate tissue ovarian tissue pancreatic tissue colorectal tissue |
| gptkbp:is_involved_in |
biomarker discovery
cellular stress response DNA repair mechanisms cellular response to stress tumor suppression pharmacogenomics cellular signaling pathways tumor progression tumor microenvironment interactions cellular apoptosis pathways cancer treatment resistance response to DNA damage response to ionizing radiation cell cycle checkpoint regulation metastatic processes therapeutic targeting strategies |
| gptkbp:is_linked_to |
genetic predisposition to cancer
inherited cancer syndromes |
| gptkbp:is_part_of |
clinical trials
genetic counseling personalized medicine approaches DNA repair pathway cancer research studies |
| gptkbp:is_regulated_by |
gptkb:ATM_protein
gptkb:ATR_protein |
| gptkbp:is_studied_for |
cancer risk assessment
|
| gptkbp:is_studied_in |
cancer genetics
|
| gptkbp:is_targeted_at |
genetic testing
|
| gptkbp:located_in |
human chromosome 22
|
| gptkbp:regulates |
cell cycle
|
| gptkbp:targets |
cancer therapies
|
| gptkbp:bfsParent |
gptkb:TP53
|
| gptkbp:bfsLayer |
5
|