|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
DNA damage
cellular stress
|
|
gptkbp:alsoKnownAs
|
gptkb:p53
gptkb:tumor_protein_p53
|
|
gptkbp:decommissioned
|
gptkb:MDM2
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:domain
|
regulatory domain
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:encodedBy
|
gptkb:TP53_gene
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:expressedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:GO
|
gptkb:GO:0008285
GO:0003677
GO:0006355
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Phosphoprotein p53
|
|
gptkbp:interactsWith
|
gptkb:ARF
gptkb:CBP/p300
gptkb:BAX
gptkb:GADD45
gptkb:p21
gptkb:gene
gptkb:MDM2
gptkb:BRCA1
gptkb:E2F1
ATM
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:molecularWeight
|
53 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:PDB
|
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
apoptosis
DNA repair
angiogenesis
cell cycle
senescence
|
|
gptkbp:significance
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
colorectal cancer
bladder cancer
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:P21554
gptkb:P04629
gptkb:P23560
gptkb:P18146
|
|
gptkbp:bfsLayer
|
7
|