|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:superoxide_dismutase_2_(SOD2)
isocitrate dehydrogenase 2 (IDH2)
|
|
gptkbp:alias
|
gptkb:NAD-dependent_protein_deacetylase_sirtuin-3
gptkb:SIR2L3
sirtuin 3
|
|
gptkbp:amendedBy
|
acetylation status of mitochondrial proteins
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:metabolic_syndrome
neurodegenerative disease
|
|
gptkbp:encodedBy
|
gptkb:SIRT3_gene
|
|
gptkbp:Entrez_Gene_ID
|
23410
|
|
gptkbp:enzymeClassification
|
gptkb:NAD-dependent_deacetylase
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.5.1
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:HGNC_ID
|
14922
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRT3
|
|
gptkbp:locatedIn
|
mitochondria
|
|
gptkbp:locatedOnChromosome
|
gptkb:human_chromosome_11p15.5
|
|
gptkbp:memberOf
|
sirtuin family
|
|
gptkbp:regulates
|
gptkb:complex_I_of_electron_transport_chain
gptkb:glutamate_dehydrogenase
gptkb:acetyl-CoA_synthetase_2
gptkb:complex_III_of_electron_transport_chain
gptkb:complex_II_of_electron_transport_chain
gptkb:complex_IV_of_electron_transport_chain
gptkb:complex_V_of_electron_transport_chain
gptkb:long-chain_acyl-CoA_dehydrogenase
gptkb:mitochondrial_permeability_transition_pore
apoptosis
cell survival
aging
inflammation
autophagy
tumor suppression
oxidative stress response
fatty acid oxidation
insulin sensitivity
mitochondrial biogenesis
thermogenesis
mitochondrial dynamics
ATP production
energy homeostasis
mitochondrial metabolism
reactive oxygen species detoxification
mitochondrial DNA repair
|
|
gptkbp:UniProtID
|
gptkb:Q9NTG7
|
|
gptkbp:bfsParent
|
gptkb:SirT
gptkb:Histone_deacetylase
gptkb:SIR-2
gptkb:P21554
|
|
gptkbp:bfsLayer
|
7
|