|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:53BP1
gptkb:Tumor_suppressor_p53-binding_protein_1
gptkb:p53BP1
|
|
gptkbp:alternativeName
|
gptkb:53BP1
gptkb:p53-binding_protein_1
|
|
gptkbp:discoveredBy
|
1997
|
|
gptkbp:domain
|
gptkb:Tudor_domain
gptkb:BRCT_domain
|
|
gptkbp:Entrez_Gene_ID
|
7158
ENSG00000108433
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:fullName
|
gptkb:Tumor_protein_p53-binding_protein_1
|
|
gptkbp:function
|
DNA damage response
DNA double-strand break repair
regulation of p53-mediated apoptosis
|
|
gptkbp:gene
|
gptkb:TP53BP1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0005634 (nucleus)
GO:0006974 (cellular response to DNA damage stimulus)
|
|
gptkbp:HGNC_ID
|
HGNC:11998
|
|
gptkbp:interactsWith
|
gptkb:53BP1
gptkb:MDC1
gptkb:p53
|
|
gptkbp:length
|
1972 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
15q15-q21
|
|
gptkbp:molecularWeight
|
213 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased cancer risk
defective DNA repair
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Tp53bp1
|
|
gptkbp:pathway
|
gptkb:cell_cycle_checkpoint
gptkb:DNA_repair_pathway
|
|
gptkbp:PDB
|
1GZH
6MXY
|
|
gptkbp:phosphorylates
|
ATM-dependent
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:role
|
genomic instability
cancer susceptibility
|
|
gptkbp:UniProtID
|
Q12888
|
|
gptkbp:bfsParent
|
gptkb:P21554
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TP53BP1
|