|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NAD-dependent_deacetylase_sirtuin-6
gptkb:SIR2L6
gptkb:Sirtuin_6
|
|
gptkbp:amendedBy
|
gptkb:histone_H3K56
gptkb:histone_H3K9
|
|
gptkbp:associatedWith
|
gptkb:cancer
metabolic disorders
premature aging
|
|
gptkbp:cofactor
|
NAD+
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodedBy
|
gptkb:SIRT6_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000124216
51548
|
|
gptkbp:expressedIn
|
human tissues
|
|
gptkbp:function
|
histone deacetylase
ADP-ribosyltransferase
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:14934
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRT6
|
|
gptkbp:involvedIn
|
aging
DNA repair
metabolism regulation
genomic stability
|
|
gptkbp:length
|
355 amino acids
|
|
gptkbp:locatedIn
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
|
|
gptkbp:memberOf
|
sirtuin family
|
|
gptkbp:molecularWeight
|
39 kDa
|
|
gptkbp:OMIM
|
606211
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:3PKI
3K35
3ZG6
|
|
gptkbp:regulates
|
apoptosis
lipid metabolism
cellular senescence
glucose metabolism
inflammation
tumor suppression
inflammatory response
glucose homeostasis
circadian rhythm
DNA double-strand break repair
telomere maintenance
fatty acid metabolism
NF-κB signaling
|
|
gptkbp:UniProtID
|
gptkb:Q8N6T7
|
|
gptkbp:bfsParent
|
gptkb:SirT
gptkb:Histone_deacetylase
gptkb:SIR-2
gptkb:P21554
|
|
gptkbp:bfsLayer
|
7
|