Statements (106)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
gptkb:Cyclin-dependent_kinase |
| gptkbp:alias |
P34 CDK6
|
| gptkbp:associated_with |
gptkb:Oncology
cell cycle regulation |
| gptkbp:code |
gptkb:cyclin-dependent_kinase_6
|
| gptkbp:function |
regulates cell cycle progression
|
| gptkbp:genetic_studies |
various cancers
|
| gptkbp:has_function |
phosphorylation of proteins
|
| gptkbp:has_gene_id |
1017
|
| gptkbp:has_role |
cell proliferation
tumorigenesis |
| gptkbp:has_symbol |
gptkb:CDK6
|
| https://www.w3.org/2000/01/rdf-schema#label |
CDK6
|
| gptkbp:initiated_by |
gptkb:Abemaciclib
gptkb:Cyclin_D1 gptkb:Cyclin_D2 gptkb:Cyclin_D3 gptkb:Palbociclib gptkb:Ribociclib p16 INK4a p21 CIP1 p27 KIP1 |
| gptkbp:interacts_with |
gptkb:Cyclin_D
gptkb:cyclin_D |
| gptkbp:involved_in |
G1 phase of cell cycle
|
| gptkbp:is_associated_with |
gptkb:Oncology
cellular senescence poor prognosis in cancers |
| gptkbp:is_essential_for |
cell cycle entry
G1/ S transition |
| gptkbp:is_expressed_in |
breast tissue
various cancers hematopoietic cells lung tissue prostate tissue normal tissues ovarian tissue skin tissue colon tissue |
| gptkbp:is_involved_in |
DNA damage response
apoptosis regulation cell cycle progression cell differentiation immune response tumor growth cellular response to stress cell cycle checkpoints neurogenesis angiogenesis metastasis cellular signaling pathways stem cell maintenance metabolic regulation cellular response to DNA damage cellular response to bacterial infection cellular response to cytokines cellular response to hormones cellular response to hypoxia cellular response to mechanical stress cellular response to oxidative stress cellular response to viral infection tumor metastasis cellular response to extracellular matrix cellular response to growth factors cellular response to growth inhibition cellular response to inflammation cellular response to metabolic stress cellular response to nutrients cellular response to immune signals cellular response to DNA repair signals cellular response to cell cycle checkpoints cellular response to cell death signals cellular response to cell division signals cellular response to cell growth signals cellular response to cell survival signals cellular response to cell-cell contact cellular response to chromatin remodeling tumor cell migration |
| gptkbp:is_linked_to |
gptkb:Oncology
poor prognosis in cancer |
| gptkbp:is_located_at |
7q21.2
|
| gptkbp:is_part_of |
gptkb:CDK_family
cell cycle machinery kinase signaling pathways |
| gptkbp:is_regulated_by |
gptkb:cyclin_D1
transcription factors RB protein micro RNAs mi RNAs |
| gptkbp:is_studied_in |
clinical trials
cancer research |
| gptkbp:is_targeted_at |
gptkb:immunotherapy
cancer therapy CDK inhibitors small molecule inhibitors gene therapy approaches |
| gptkbp:located_in |
gptkb:Atom
chromosome 7 |
| gptkbp:promoter |
CDK6 gene
|
| gptkbp:regulates |
gptkb:retinoblastoma_protein_(Rb)
cell proliferation |
| gptkbp:bfsParent |
gptkb:mi_R-34
gptkb:abemaciclib gptkb:Cyclin-dependent_kinase |
| gptkbp:bfsLayer |
6
|