|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
|
|
gptkbp:discoveredBy
|
1994
|
|
gptkbp:encodedBy
|
gptkb:CDK6_gene
|
|
gptkbp:Entrez_Gene_ID
|
1021
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.22
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_6
|
|
gptkbp:function
|
regulation of cell cycle
G1 phase progression
|
|
gptkbp:gene
|
gptkb:CDK6
|
|
gptkbp:HGNC_ID
|
HGNC:1777
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK6
|
|
gptkbp:inhibitedBy
|
gptkb:palbociclib
gptkb:ribociclib
gptkb:abemaciclib
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_D2
gptkb:Cyclin_D3
gptkb:Cyclin_D1
|
|
gptkbp:involvedIn
|
cell proliferation
tumorigenesis
hematopoiesis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7q21.2
|
|
gptkbp:molecularWeight
|
36 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
leukemia
|
|
gptkbp:OMIM
|
603368
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdk6
|
|
gptkbp:PDB
|
gptkb:1G3N
2EUF
|
|
gptkbp:phosphorylates
|
gptkb:RB1
p107
p130
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
transcription
cell cycle G1/S transition
|
|
gptkbp:reviewedBy
|
gptkb:Cell_Cycle
gptkb:Nature_Reviews_Cancer
gptkb:Oncogene
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q00534
|
|
gptkbp:bfsParent
|
gptkb:umbraliciclib
gptkb:EGR1
gptkb:purvalanol_A
gptkb:flavopiridol
gptkb:WAF1_gene
gptkb:RB1
gptkb:G1
gptkb:CDKN2A
|
|
gptkbp:bfsLayer
|
6
|