|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Cell_division_protein_kinase_4
gptkb:Serine/threonine-protein_kinase_CDK4
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
melanoma
|
|
gptkbp:discoveredBy
|
gptkb:Sherr_CJ
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodedBy
|
gptkb:CDK4_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000135446
1019
|
|
gptkbp:enzymeClassification
|
serine/threonine protein kinase
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_4
|
|
gptkbp:function
|
regulation of cell cycle
cyclin-dependent protein serine/threonine kinase activity
|
|
gptkbp:gene
|
gptkb:CDK4
|
|
gptkbp:GOProcess
|
G1/S transition of mitotic cell cycle
|
|
gptkbp:HGNC_ID
|
1773
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK4
|
|
gptkbp:inhibitedBy
|
gptkb:p15INK4b
gptkb:p16INK4a
gptkb:p18INK4c
gptkb:p19INK4d
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_D2
gptkb:Cyclin_D3
gptkb:Cyclin_D1
|
|
gptkbp:locatedOnChromosome
|
12q14
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdk4
|
|
gptkbp:partOf
|
gptkb:Cyclin_D-CDK4_complex
|
|
gptkbp:PDB
|
gptkb:2W96
3G33
|
|
gptkbp:phosphorylates
|
gptkb:RB1
p107
p130
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
gptkb:NM_000075
|
|
gptkbp:regulates
|
cell proliferation
cell cycle progression
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:targetOfDrug
|
gptkb:palbociclib
gptkb:ribociclib
gptkb:abemaciclib
|
|
gptkbp:UniProtID
|
P11802
|
|
gptkbp:bfsParent
|
gptkb:umbraliciclib
gptkb:EGR1
gptkb:purvalanol_A
gptkb:flavopiridol
gptkb:WAF1_gene
gptkb:RB1
gptkb:p21
gptkb:p27
gptkb:chromosome_12
gptkb:G1
gptkb:CDKN2A
|
|
gptkbp:bfsLayer
|
6
|