|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
Asp178
His180
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Cornelia_de_Lange_syndrome
cell cycle regulation
transcriptional repression
chromatin remodeling
|
|
gptkbp:cofactor
|
Zn2+
|
|
gptkbp:discoveredBy
|
2002
|
|
gptkbp:encodedBy
|
gptkb:HDAC8_gene
|
|
gptkbp:Entrez_Gene_ID
|
55869
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.5.1.98
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:family
|
histone deacetylase family
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_8
|
|
gptkbp:function
|
regulation of gene expression
histone deacetylation
|
|
gptkbp:gene
|
gptkb:HDAC8
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:14064
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC8
|
|
gptkbp:inhibitedBy
|
gptkb:trichostatin_A
gptkb:romidepsin
gptkb:PCI-34051
|
|
gptkbp:interactsWith
|
gptkb:SMC3
gptkb:cohesin_complex
transcriptional repressors
|
|
gptkbp:locatedOnChromosome
|
Xq13.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~42 kDa
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
|
|
gptkbp:OMIM
|
300269
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Hdac8
gptkb:rat_Hdac8
|
|
gptkbp:pathway
|
gptkb:Notch_signaling_pathway
gptkb:Wnt_signaling_pathway
epigenetic regulation
|
|
gptkbp:PDB
|
gptkb:1T64
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:RefSeq
|
gptkb:NM_018486
|
|
gptkbp:structure
|
alpha/beta fold
|
|
gptkbp:subfamily
|
gptkb:class_I_HDAC
|
|
gptkbp:substrate
|
acetylated lysine residues
|
|
gptkbp:UniProtID
|
gptkb:Q9BY41
|
|
gptkbp:bfsParent
|
gptkb:Histone_deacetylase
gptkb:P21554
|
|
gptkbp:bfsLayer
|
7
|