|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:p53
|
|
gptkbp:alsoKnownAs
|
gptkb:p21
gptkb:CIP1
gptkb:WAF1
|
|
gptkbp:biologicalProcess
|
CDK inhibitor
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:encodes
|
gptkb:p21_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000124762
1026
|
|
gptkbp:expressedIn
|
many human tissues
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1784
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDKN1A
|
|
gptkbp:inhibitedBy
|
gptkb:cyclin-dependent_kinases
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:cyclin_D
gptkb:GADD45
gptkb:CDK2
gptkb:CDK4
gptkb:PCNA
gptkb:SET_protein
gptkb:cyclin_E
|
|
gptkbp:involvedIn
|
apoptosis
cellular senescence
DNA damage response
tumor suppression
cell cycle arrest
|
|
gptkbp:length
|
164 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn1a
|
|
gptkbp:phosphorylates
|
gptkb:AKT
gptkb:CDK2
|
|
gptkbp:proteinFamily
|
CDK-interacting domain
PCNA-binding domain
|
|
gptkbp:regulates
|
gptkb:FOXO_proteins
gptkb:p63
gptkb:p73
gptkb:SP1
gptkb:STAT_proteins
gptkb:BRCA1
gptkb:p53
gptkb:G1/S_transition
gptkb:MYC
gptkb:E2F
gptkb:NF-κB
gptkb:SMAD_proteins
cell cycle
histone modification
epigenetic regulation
transcriptional regulation
G2/M transition
|
|
gptkbp:UniProtID
|
gptkb:P38936
|
|
gptkbp:bfsParent
|
gptkb:EGR1
gptkb:WAF1_gene
gptkb:p21
gptkb:CDKN1C
gptkb:p53
gptkb:CDKN2A
|
|
gptkbp:bfsLayer
|
6
|