|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
cardiac hypertrophy
|
|
gptkbp:discoveredBy
|
gptkb:Grozinger_et_al.
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:encodedBy
|
gptkb:HDAC4_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000068024
|
|
gptkbp:family
|
gptkb:class_IIa_histone_deacetylase
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_4
|
|
gptkbp:function
|
histone deacetylase activity
transcriptional repression
|
|
gptkbp:gene
|
gptkb:HDAC4
|
|
gptkbp:GO
|
GO:0004407
GO:0006355
|
|
gptkbp:HGNC_ID
|
14065
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC4
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:MEF2C
gptkb:HDAC3
|
|
gptkbp:involvedIn
|
neuronal survival
skeletal development
muscle differentiation
|
|
gptkbp:length
|
1084 amino acids
|
|
gptkbp:locatedOnChromosome
|
2q37.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
120 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2VQJ
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:RefSeq
|
gptkb:NM_006037
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:UniProtID
|
gptkb:P56524
|
|
gptkbp:bfsParent
|
gptkb:MEF2C
gptkb:Histone_deacetylase
gptkb:P21554
|
|
gptkbp:bfsLayer
|
7
|