|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:RPD3
gptkb:HD2
gptkb:YAF1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
NAD-independent histone deacetylase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
histone deacetylase research community
|
|
gptkbp:encodedBy
|
gptkb:HDAC2_gene
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.5.1.98
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1996
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_2
|
|
gptkbp:function
|
regulation of gene expression
histone deacetylation
|
|
gptkbp:gene
|
gptkb:HDAC2
|
|
gptkbp:GO
|
GO:0004407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC2
|
|
gptkbp:inhibitedBy
|
gptkb:valproic_acid
gptkb:sodium_butyrate
gptkb:trichostatin_A
|
|
gptkbp:interactsWith
|
gptkb:CoREST
gptkb:YY1
gptkb:HDAC1
gptkb:Sin3A
MTA2
|
|
gptkbp:length
|
488 amino acids
|
|
gptkbp:locatedOnChromosome
|
1q21
|
|
gptkbp:memberOf
|
gptkb:class_I_HDACs
histone deacetylase family
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:participatedIn
|
transcriptional repression
chromatin remodeling
|
|
gptkbp:PDB
|
4LY1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NP_001518
|
|
gptkbp:regulates
|
gptkb:synaptic_plasticity
apoptosis
cell cycle
|
|
gptkbp:target
|
HDAC inhibitors
|
|
gptkbp:UniProtID
|
Q92769
|
|
gptkbp:bfsParent
|
gptkb:vorinostat
|
|
gptkbp:bfsLayer
|
6
|