|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:SIR2L2
gptkb:sirtuin_2
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:cancer
|
|
gptkbp:crystalSystem
|
gptkb:PDB:_5DY5
gptkb:PDB:_5MAT
PDB: 4R8M
|
|
gptkbp:encodedBy
|
gptkb:SIRT2_gene
|
|
gptkbp:Entrez_Gene_ID
|
22933
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:hasBiologicalActivity
|
gptkb:NAD-dependent_deacetylase
|
|
gptkbp:hasIsoform
|
2
|
|
gptkbp:HGNC_ID
|
14922
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRT2
|
|
gptkbp:inhibitedBy
|
gptkb:AGK2
gptkb:SirReal2
gptkb:AK-7
|
|
gptkbp:interactsWith
|
gptkb:FOXO3
gptkb:p53
gptkb:α-tubulin
|
|
gptkbp:involvedIn
|
aging
cell cycle regulation
neurodegeneration
metabolic regulation
|
|
gptkbp:locatedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
19q13.32
|
|
gptkbp:memberOf
|
sirtuin family
|
|
gptkbp:molecularWeight
|
43 kDa
|
|
gptkbp:OMIM
|
604144
|
|
gptkbp:orthologInMouse
|
gptkb:Sirt2
|
|
gptkbp:regulates
|
lipid metabolism
inflammation
microtubule dynamics
oxidative stress response
gluconeogenesis
acetylation of α-tubulin
|
|
gptkbp:UniProtID
|
Q8IXJ6
|
|
gptkbp:bfsParent
|
gptkb:SirT
gptkb:Histone_deacetylase
gptkb:SIR-2
gptkb:P21554
|
|
gptkbp:bfsLayer
|
7
|