Cellular tumor antigen p53

URI: https://gptkb.org/entity/Cellular_tumor_antigen_p53
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:p53
gptkb:tumor_protein_p53
gptkbp:discoveredBy gptkb:Arnold_Levine
gptkb:David_Lane
gptkbp:discoveredIn 1979
gptkbp:encodedBy gptkb:TP53_gene
gptkbp:Entrez_Gene_ID 7157
gptkbp:expressedIn gptkb:nucleus
gptkb:cytoplasm
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function tumor suppressor
transcription factor
gptkbp:HGNC_ID 11998
https://www.w3.org/2000/01/rdf-schema#label Cellular tumor antigen p53
gptkbp:interactsWith gptkb:BAX
gptkb:p21
gptkb:MDM2
gptkb:BRCA1
ATM
gptkbp:locatedOnChromosome 17p13.1
gptkbp:molecularWeight 53 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
gptkbp:OMIM 191170
gptkbp:PDB 1TUP
gptkbp:postTranslationalModification phosphorylation
methylation
sumoylation
ubiquitination
acetylation
gptkbp:regulates apoptosis
DNA repair
cell cycle
senescence
genomic stability
gptkbp:role gptkb:Li-Fraumeni_syndrome
cell differentiation
cellular senescence
cell migration
immune response
DNA damage response
autophagy
cell adhesion
cellular stress response
metabolism regulation
angiogenesis inhibition
stem cell regulation
gptkbp:structure tetramer
gptkbp:UniProtID P04637
gptkbp:bfsParent gptkb:P35222
gptkbp:bfsLayer 6