Tumor protein p53 (human)

URI: https://gptkb.org/entity/Tumor_protein_p53_(human)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:p53 gptkb:cellular_tumor_antigen_p53 gptkb:antigen_NY-CO-13 gptkb:phosphoprotein_p53 gptkb:tumor_suppressor_p53
gptkbp:discoveredBy	gptkb:Arnold_J._Levine gptkb:David_P._Lane gptkb:Lloyd_J._Old
gptkbp:discoveredIn	1979
gptkbp:domain	regulatory domain DNA-binding domain oligomerization domain transactivation domain
gptkbp:function	tumor suppressor transcription factor
gptkbp:gene	gptkb:TP53
https://www.w3.org/2000/01/rdf-schema#label	Tumor protein p53 (human)
gptkbp:interactsWith	gptkb:ATR gptkb:BAX gptkb:GADD45 gptkb:p21 gptkb:CREB-binding_protein gptkb:MDM2 gptkb:BRCA1 gptkb:E2F1 ATM
gptkbp:locatedOnChromosome	17p13.1
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:molecularWeight	~43.7 kDa
gptkbp:mutationAssociatedWith	gptkb:cancer gptkb:Li-Fraumeni_syndrome colorectal cancer melanoma pancreatic cancer prostate cancer brain cancer bladder cancer deletion insertion missense mutation nonsense mutation frameshift mutation
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:PDB	1TUP
gptkbp:postTranslationalModification	phosphorylation methylation sumoylation ubiquitination acetylation
gptkbp:regulates	apoptosis DNA repair angiogenesis cell cycle senescence
gptkbp:UniProtID	P04637
gptkbp:bfsParent	gptkb:P21554
gptkbp:bfsLayer	7