|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:GON-10
gptkb:HD1
gptkb:RPD3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
cell cycle regulation
chromatin modification
histone deacetylase activity
transcriptional repression
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
Taunton et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodedBy
|
gptkb:HDAC1_gene
|
|
gptkbp:Entrez_Gene_ID
|
3065
ENSG00000116478
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.5.1.98
|
|
gptkbp:fullName
|
gptkb:Histone_deacetylase_1
|
|
gptkbp:function
|
regulation of gene expression
histone deacetylation
|
|
gptkbp:gene
|
gptkb:HDAC1
|
|
gptkbp:GO
|
GO:0004407
|
|
gptkbp:HGNC_ID
|
4852
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC1
|
|
gptkbp:inhibitedBy
|
gptkb:valproic_acid
gptkb:sodium_butyrate
gptkb:trichostatin_A
|
|
gptkbp:interactsWith
|
gptkb:HDAC2
gptkb:RB1
gptkb:CoREST
gptkb:NuRD_complex
gptkb:SIN3A
gptkb:YY1
MTA2
|
|
gptkbp:length
|
482 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p35.2
|
|
gptkbp:memberOf
|
gptkb:class_I_HDACs
histone deacetylase family
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:OMIM
|
601241
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
4BKX
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
acetylation
|
|
gptkbp:RefSeq
|
NP_004955
|
|
gptkbp:UniProtID
|
Q13547
|
|
gptkbp:bfsParent
|
gptkb:RB1
gptkb:vorinostat
|
|
gptkbp:bfsLayer
|
6
|