|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:TP53
gptkb:cellular_tumor_antigen_p53
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_Levine
gptkb:David_Lane
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:domain
|
regulatory domain
DNA-binding domain
oligomerization domain
transactivation domain
|
|
gptkbp:encodedBy
|
gptkb:TP53_gene
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:expressedIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tumor suppressor p53
|
|
gptkbp:interactsWith
|
gptkb:BAX
gptkb:GADD45
gptkb:p21
gptkb:MDM2
gptkb:BRCA1
gptkb:E2F1
ATM
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:molecularWeight
|
53 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Li-Fraumeni_syndrome
deletion
missense mutation
nonsense mutation
frameshift mutation
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:PDB
|
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
apoptosis
DNA repair
metabolism
angiogenesis
cell cycle
senescence
|
|
gptkbp:role
|
tumor suppression
cellular stress response
genomic stability
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:NP_004976
gptkb:P21554
gptkb:P04629
gptkb:P23560
gptkb:P18146
|
|
gptkbp:bfsLayer
|
7
|