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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Protein_kinase_B_alpha
gptkb:RAC-alpha_serine/threonine-protein_kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Proteus_syndrome
|
|
gptkbp:encodedBy
|
gptkb:AKT1_gene
|
|
gptkbp:function
|
serine/threonine kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT1 protein
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
cell proliferation
cell survival
cell growth
glucose metabolism
apoptosis inhibition
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
4EJN
|
|
gptkbp:phosphorylates
|
Ser473
Thr308
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
gptkb:FOXO1
gptkb:FOXO3
gptkb:FOXO4
gptkb:FOXO6
gptkb:GAB2
gptkb:GSK3A
gptkb:GSK3B
gptkb:Mdm2
gptkb:PRAS40
gptkb:TSC1
gptkb:TSC2
gptkb:CREB
gptkb:GLUT4
gptkb:Rb_protein
gptkb:BAD
gptkb:Cyclin_B1
gptkb:YAP
gptkb:Cyclin_A
gptkb:Cyclin_E
gptkb:p21
gptkb:p27
gptkb:Caspase-9
gptkb:IKK
gptkb:NF-kB
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:GSK3
gptkb:MDM2
gptkb:mTOR
gptkb:mTORC1
gptkb:mTORC2
gptkb:Cyclin_D1
gptkb:E2F_transcription_factors
gptkb:p53
gptkb:BCL2
gptkb:MST2
gptkb:eNOS
gptkb:p27kip1
gptkb:p70S6K
BIM
ASK1
CDK inhibitors
IKK-alpha
TBC1D4
p21cip1
|
|
gptkbp:UniProtID
|
gptkb:P31749
|
|
gptkbp:bfsParent
|
gptkb:RAF1_protein
|
|
gptkbp:bfsLayer
|
7
|