|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:component
|
gptkb:DEPTOR
gptkb:PROTOR1
gptkb:PROTOR2
gptkb:RICTOR
gptkb:mLST8
gptkb:mSIN1
gptkb:mTOR
|
|
gptkbp:discoveredIn
|
2004
|
|
gptkbp:downstreamOf
|
gptkb:PKCα
gptkb:SGK1
gptkb:AKT
|
|
gptkbp:fullName
|
gptkb:mechanistic_target_of_rapamycin_complex_2
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell survival
regulation of cytoskeleton
regulation of metabolism
|
|
gptkbp:gene
|
gptkb:DEPTOR
gptkb:MAPKAP1
gptkb:MLST8
gptkb:MTOR
gptkb:PRR5
gptkb:PRR5L
gptkb:RICTOR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mTORC2
|
|
gptkbp:insensitiveTo
|
acute rapamycin
|
|
gptkbp:involves
|
gptkb:cancer
gptkb:diabetes
aging
obesity
neurodegenerative diseases
|
|
gptkbp:kinaseActivity
|
serine/threonine protein kinase
|
|
gptkbp:locale
|
gptkb:endoplasmic_reticulum
gptkb:cytoplasm
gptkb:plasma_membrane
mitochondria
|
|
gptkbp:phosphorylates
|
gptkb:PKCα
gptkb:SGK1
gptkb:AKT
|
|
gptkbp:regulates
|
cell survival
lipid metabolism
cell migration
actin cytoskeleton
insulin signaling
|
|
gptkbp:relatedTo
|
gptkb:mTORC1
|
|
gptkbp:sensitivity
|
rapamycin (indirectly, chronic exposure)
|
|
gptkbp:upregulatedBy
|
gptkb:PI3K
gptkb:insulin
growth factors
|
|
gptkbp:bfsParent
|
gptkb:PI3K/AKT/mTOR_pathway
gptkb:PI3K/AKT_pathway
gptkb:mTOR_pathway
|
|
gptkbp:bfsLayer
|
5
|