|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:p53
|
|
gptkbp:alsoKnownAs
|
gptkb:CDKN1A
gptkb:cyclin-dependent_kinase_inhibitor_1
|
|
gptkbp:degradedBy
|
gptkb:SCFSkp2_complex
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:encodedBy
|
gptkb:CDKN1A_gene
|
|
gptkbp:Entrez_Gene_ID
|
1026
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cell cycle regulation
|
|
gptkbp:gene
|
gptkb:CDKN1A
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p21
|
|
gptkbp:inhibitedBy
|
gptkb:cyclin-dependent_kinases
|
|
gptkbp:interactsWith
|
gptkb:cyclin_D
gptkb:GADD45
gptkb:CDK2
gptkb:CDK4
gptkb:PCNA
gptkb:cyclin_E
|
|
gptkbp:involvedIn
|
cell differentiation
aging
wound healing
cell cycle arrest
response to oxidative stress
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.2
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
premature aging syndromes
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1AXC
|
|
gptkbp:phosphorylates
|
gptkb:AKT
PKA
|
|
gptkbp:regulates
|
gptkb:Sp1
gptkb:STAT_proteins
gptkb:p53
gptkb:TGF-beta
gptkb:E2F
G1 phase of cell cycle
|
|
gptkbp:role
|
apoptosis
cellular senescence
DNA damage response
tumor suppression
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:UniProtID
|
gptkb:P38936
|
|
gptkbp:bfsParent
|
gptkb:cdc2
|
|
gptkbp:bfsLayer
|
5
|