|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:bradykinin
gptkb:vascular_endothelial_growth_factor_(VEGF)
gptkb:acetylcholine
shear stress
|
|
gptkbp:alternativeName
|
NOS3
constitutive NOS
endothelial NOS
|
|
gptkbp:associatedWith
|
gptkb:diabetes_mellitus
atherosclerosis
hypertension
coronary artery disease
erectile dysfunction
|
|
gptkbp:cofactor
|
gptkb:calmodulin
gptkb:FMN
gptkb:FAD
NADPH
tetrahydrobiopterin (BH4)
|
|
gptkbp:discoveredBy
|
Salvatore Moncada (NO pathway)
|
|
gptkbp:EC_number
|
1.14.13.39
|
|
gptkbp:encodedBy
|
NOS3 gene
|
|
gptkbp:fullName
|
gptkb:endothelial_nitric_oxide_synthase
|
|
gptkbp:function
|
synthesizes nitric oxide (NO) from L-arginine
|
|
gptkbp:gene
|
NOS3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
eNOS
|
|
gptkbp:inhibitedBy
|
gptkb:caveolin-1
asymmetric dimethylarginine (ADMA)
|
|
gptkbp:locatedOnChromosome
|
chromosome 7q36
|
|
gptkbp:location
|
gptkb:Golgi_apparatus
gptkb:plasma_membrane
endothelial cells
|
|
gptkbp:molecularWeight
|
~135 kDa
|
|
gptkbp:orthologIn
|
iNOS
nNOS
|
|
gptkbp:product
|
L-citrulline
nitric oxide (NO)
|
|
gptkbp:regulates
|
phosphorylation
AMPK-mediated phosphorylation
Akt-mediated phosphorylation
calcium/calmodulin binding
caveolin-1 binding
|
|
gptkbp:role
|
regulation of blood pressure
vasodilation
inhibition of platelet aggregation
prevention of atherosclerosis
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:L-arginine
|
|
gptkbp:UniProtID
|
P29474
|
|
gptkbp:bfsParent
|
gptkb:AKT1
gptkb:PI3K-AKT_signaling_pathway
gptkb:AMPK_pathway
|
|
gptkbp:bfsLayer
|
6
|