FOXO transcription factors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatedBy	dephosphorylation
gptkbp:alternativeName	gptkb:FOXO_proteins gptkb:Forkhead_box_O_transcription_factors
gptkbp:binds	gptkb:gene DAF-16 binding element
gptkbp:bindsCofactor	gptkb:14-3-3_proteins
gptkbp:contains	gptkb:FOXO1 gptkb:FOXO3 gptkb:FOXO4 gptkb:FOXO6
gptkbp:decommissioned	phosphorylation
gptkbp:discoveredIn	1990s
gptkbp:exportedFromNucleusBy	phosphorylation
gptkbp:expressedIn	mammals vertebrates
gptkbp:function	transcription regulation
gptkbp:gene	gptkb:FOXO
https://www.w3.org/2000/01/rdf-schema#label	FOXO transcription factors
gptkbp:involves	gptkb:cancer gptkb:diabetes aging neurodegenerative diseases
gptkbp:locale	gptkb:nucleus gptkb:cytoplasm
gptkbp:memberOf	gptkb:Forkhead_box_(FOX)_protein_family
gptkbp:orthologIn	gptkb:C._elegans_DAF-16 gptkb:Drosophila_dFOXO
gptkbp:phosphorylates	gptkb:Akt_kinase
gptkbp:proteinFamily	gptkb:FOXO
gptkbp:regulates	apoptosis longevity DNA repair metabolism growth factors cell cycle oxidative stress response insulin signaling stress signals
gptkbp:reviewedBy	gptkb:Cell_Metabolism gptkb:Annual_Review_of_Biochemistry gptkb:Nature_Reviews_Molecular_Cell_Biology
gptkbp:bfsParent	gptkb:AKT_signaling_pathway gptkb:PI3K/AKT_pathway
gptkbp:bfsLayer	5