E2F transcription factors

URI: https://gptkb.org/entity/E2F_transcription_factors
GPTKB entity
Statements (42)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy genes required for S phase
gptkbp:associatedWith gptkb:cancer
tumorigenesis
gptkbp:binds gptkb:gene
gptkbp:component E2F-Rb pathway
gptkbp:discoveredIn 1990s
gptkbp:domain DNA-binding domain
dimerization domain
gptkbp:expressedIn eukaryotic cells
gptkbp:formsComplexWith gptkb:DP_proteins
gptkbp:function regulation of cell cycle
regulation of gene expression
control of DNA replication
gptkbp:hasMember gptkb:E2F2
gptkb:E2F3
gptkb:E2F4
gptkb:E2F5
gptkb:E2F6
gptkb:E2F7
gptkb:E2F8
gptkb:E2F1
https://www.w3.org/2000/01/rdf-schema#label E2F transcription factors
gptkbp:inhibitedBy gptkb:retinoblastoma_protein
gptkbp:interactsWith gptkb:retinoblastoma_protein
gptkbp:locatedOnChromosome various chromosomes in humans
gptkbp:orthologIn gptkb:yeast
gptkb:Drosophila_melanogaster
mammals
plants
gptkbp:regulates gptkb:G1/S_transition
gptkb:cyclin-dependent_kinases
apoptosis
cell proliferation
differentiation
DNA repair
cellular senescence
phosphorylation
S phase entry
gptkbp:represses genes involved in cell cycle exit
gptkbp:bfsParent gptkb:RB1
gptkbp:bfsLayer 6