|
gptkbp:instanceOf
|
gptkb:tumor_suppressor
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:pRb
gptkb:retinoblastoma_protein
|
|
gptkbp:discoveredBy
|
gptkb:Weinberg_laboratory
|
|
gptkbp:encodedBy
|
gptkb:RB1_gene
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulation of cell cycle
inhibition of E2F transcription factors
prevention of excessive cell growth
|
|
gptkbp:inhibitedBy
|
cell proliferation
|
|
gptkbp:interactsWith
|
gptkb:p16INK4a
gptkb:E2F1
gptkb:HDAC1
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma
osteosarcoma
|
|
gptkbp:namedAfter
|
gptkb:retinoblastoma
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:phosphorylates
|
gptkb:cyclin-dependent_kinases
inactive
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
G1/S cell cycle checkpoint
|
|
gptkbp:role
|
gptkb:mitotic_checkpoint
gptkb:immune_response
gptkb:cellular_stress_response
apoptosis
development
differentiation
metabolism
cellular senescence
angiogenesis
stem cell maintenance
epigenetic regulation
tumor suppression
transcriptional repression
chromatin remodeling
chromosome stability
response to DNA damage
DNA replication control
|
|
gptkbp:structure
|
pocket domain
|
|
gptkbp:unphosphorylatedForm
|
active
|
|
gptkbp:bfsParent
|
gptkb:E1A
gptkb:G1
gptkb:PHB1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Rb protein
|