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gptkbp:instanceOf
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gptkb:protein
tumor suppressor
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gptkbp:alternativeName
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gptkb:pRb
gptkb:retinoblastoma_protein
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gptkbp:discoveredBy
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gptkb:Weinberg_laboratory
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gptkbp:encodedBy
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gptkb:RB1_gene
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
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regulation of cell cycle
inhibition of E2F transcription factors
prevention of excessive cell growth
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https://www.w3.org/2000/01/rdf-schema#label
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Rb protein
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gptkbp:inhibitedBy
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cell proliferation
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gptkbp:interactsWith
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gptkb:p16INK4a
gptkb:E2F1
gptkb:HDAC1
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gptkbp:locale
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gptkb:nucleus
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gptkbp:molecularWeight
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~110 kDa
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gptkbp:mutationAssociatedWith
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gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma
osteosarcoma
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gptkbp:namedAfter
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gptkb:retinoblastoma
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gptkbp:orthologIn
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gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
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gptkbp:phosphorylates
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gptkb:cyclin-dependent_kinases
inactive
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gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
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gptkbp:regulates
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G1/S cell cycle checkpoint
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gptkbp:role
|
gptkb:mitotic_checkpoint
apoptosis
development
differentiation
metabolism
cellular senescence
angiogenesis
immune response
stem cell maintenance
epigenetic regulation
tumor suppression
cellular stress response
transcriptional repression
chromatin remodeling
chromosome stability
response to DNA damage
DNA replication control
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gptkbp:structure
|
pocket domain
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gptkbp:unphosphorylatedForm
|
active
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gptkbp:bfsParent
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gptkb:G1
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gptkbp:bfsLayer
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6
|