|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:AKT1
gptkb:RAC-alpha_serine/threonine-protein_kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes_mellitus
gptkb:Proteus_syndrome
|
|
gptkbp:discoveredBy
|
gptkb:Staal_et_al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:AKT1_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:function
|
serine/threonine kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Protein kinase B alpha
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
cell proliferation
cell survival
cell growth
glucose metabolism
apoptosis inhibition
|
|
gptkbp:locatedOnChromosome
|
14q32.33
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:phosphorylates
|
gptkb:PDK1
gptkb:mTORC2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
gptkb:TSC2
gptkb:CREB
gptkb:p21
gptkb:NF-kB
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:GSK3
gptkb:MDM2
gptkb:mTOR
gptkb:eNOS
gptkb:p27_Kip1
apoptosis
cell differentiation
DNA repair
angiogenesis
cell cycle progression
cell migration
glucose uptake
protein synthesis
glycogen synthesis
CDK inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P31749
|
|
gptkbp:bfsParent
|
gptkb:AKT1
|
|
gptkbp:bfsLayer
|
6
|