|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:insulin
growth factors
amino acids
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes
aging
neurodegeneration
|
|
gptkbp:component
|
gptkb:Deptor
gptkb:PRAS40
gptkb:mLST8
gptkb:bird
gptkb:mTOR
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:downstreamOf
|
gptkb:4E-BP1
gptkb:HIF-1α
gptkb:S6K1
gptkb:ULK1
|
|
gptkbp:fullName
|
gptkb:mechanistic_target_of_rapamycin_complex_1
|
|
gptkbp:function
|
regulation of autophagy
regulation of cell growth
regulation of metabolism
regulation of protein synthesis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mTORC1
|
|
gptkbp:inhibitedBy
|
gptkb:rapamycin
gptkb:hypoxia
energy stress
nutrient deprivation
|
|
gptkbp:location
|
gptkb:cytoplasm
lysosomal membrane
|
|
gptkbp:phosphorylates
|
gptkb:4E-BP1
gptkb:S6K1
|
|
gptkbp:regulates
|
lipid synthesis
autophagy inhibition
nucleotide synthesis
ribosome biogenesis
|
|
gptkbp:relatedTo
|
gptkb:mTORC2
gptkb:mTOR_pathway
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:target
|
gptkb:everolimus
gptkb:rapalogs
gptkb:temsirolimus
|
|
gptkbp:upregulatedBy
|
gptkb:Rag_GTPases
gptkb:AMPK
gptkb:Rheb
gptkb:TSC1/TSC2_complex
|
|
gptkbp:bfsParent
|
gptkb:PI3K/AKT/mTOR_pathway
gptkb:PI3K/AKT_pathway
gptkb:mTOR_pathway
|
|
gptkbp:bfsLayer
|
5
|