|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
phosphorylation
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:depression
drug addiction
|
|
gptkbp:binds
|
gptkb:cAMP_response_element_(CRE)
|
|
gptkbp:discoveredBy
|
gptkb:Marc_Montminy
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:domain
|
basic leucine zipper (bZIP) domain
|
|
gptkbp:encodedBy
|
gptkb:CREB1_gene
|
|
gptkbp:foundIn
|
gptkb:nucleus
|
|
gptkbp:fullName
|
gptkb:cAMP_response_element-binding_protein
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:gene
|
gptkb:CREB
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CREB
|
|
gptkbp:interactsWith
|
gptkb:CBP_(CREB-binding_protein)
gptkb:p300
|
|
gptkbp:involvedIn
|
cell survival
metabolism
neuronal plasticity
memory formation
|
|
gptkbp:locatedOnChromosome
|
2q34
|
|
gptkbp:molecularWeight
|
~43 kDa
|
|
gptkbp:OMIM
|
123810
|
|
gptkbp:phosphorylates
|
gptkb:protein_kinase_A
gptkb:Ca2+/calmodulin-dependent_protein_kinases
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
gptkb:BDNF_gene
gptkb:c-fos_gene
gptkb:somatostatin_gene
gptkb:tyrosine_hydroxylase_gene
gene expression
metabolic genes
immediate early genes
neuronal genes
|
|
gptkbp:relatedTo
|
gptkb:CREM
gptkb:ATF-1
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
monomer or dimer
|
|
gptkbp:UniProtID
|
P16220
|
|
gptkbp:bfsParent
|
gptkb:AKT1
gptkb:PI3K-AKT_signaling_pathway
gptkb:AMPK_pathway
gptkb:p38_MAPK_pathway
|
|
gptkbp:bfsLayer
|
6
|