|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:E3_ubiquitin-protein_ligase_Mdm2
gptkb:HDMX
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:discoveredBy
|
gptkb:Arnold_J._Levine
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:domain
|
RING finger domain
Acidic domain
Zinc finger domain
p53-binding domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000135679
4193
|
|
gptkbp:fullName
|
gptkb:Mouse_double_minute_2_homolog
|
|
gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
|
|
gptkbp:gene
|
gptkb:MDM2
|
|
gptkbp:geneType
|
tumor suppressor
|
|
gptkbp:HGNC_ID
|
6973
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Mdm2
|
|
gptkbp:inhibitedBy
|
gptkb:p53
|
|
gptkbp:interactsWith
|
gptkb:MDMX
gptkb:p14ARF
gptkb:Ribosomal_proteins
|
|
gptkbp:length
|
491 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:12q15
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:negativeRegulatorOf
|
p53-mediated transcription
|
|
gptkbp:OMIM
|
164785
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
|
|
gptkbp:pathway
|
p53 signaling pathway
|
|
gptkbp:PDB
|
gptkb:4XXB
1Z1M
|
|
gptkbp:phosphorylates
|
Ser166
Ser395
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:p53
apoptosis
cell cycle
|
|
gptkbp:target
|
gptkb:RG7112
gptkb:MI-219
gptkb:Nutlin-3
|
|
gptkbp:UniProtID
|
gptkb:Q00987
|
|
gptkbp:bfsParent
|
gptkb:AKT1
gptkb:WAF1_gene
gptkb:MDM2
|
|
gptkbp:bfsLayer
|
6
|