Statements (75)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
ATM
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:clinical_trial |
potential drug target
|
| gptkbp:form |
Mdm2-p53 complex
|
| gptkbp:function |
ubiquitin ligase
|
| gptkbp:has_binding_site |
gptkb:p53
|
| gptkbp:has_role |
negative regulator of p53
|
| https://www.w3.org/2000/01/rdf-schema#label |
Mdm2
|
| gptkbp:initiated_by |
gptkb:nutlin-3
p53 transcriptional activity |
| gptkbp:interacts_with |
gptkb:p53
|
| gptkbp:involved_in |
cell cycle regulation
tumorigenesis |
| gptkbp:is_associated_with |
chronic diseases
genetic mutations disease progression metastasis poor prognosis |
| gptkbp:is_deubiquitinated_by |
gptkb:USP7
|
| gptkbp:is_expressed_in |
various tissues
cancer stem cells tumor cells embryonic stem cells normal tissues neoplastic tissues tumor microenvironments |
| gptkbp:is_involved_in |
DNA damage response
apoptosis regulation cellular homeostasis cellular metabolism cellular stress response immune response signal transduction DNA repair mechanisms cellular proliferation cellular response to stress cellular senescence tumor suppression cellular aging cellular differentiation cellular signaling pathways cellular signaling cascades tumor microenvironment interactions cellular differentiation pathways cellular signaling networks cellular growth regulation cellular repair processes cellular apoptosis pathways cellular stress adaptation |
| gptkbp:is_linked_to |
tumor progression
therapeutic resistance chemoresistance viral oncogenesis |
| gptkbp:is_overexpressed_in |
various cancers
|
| gptkbp:is_part_of |
oncogenic signaling pathways
p53 pathway |
| gptkbp:is_regulated_by |
transcription factors
ARF mi RNAs |
| gptkbp:is_studied_for |
therapeutic interventions
biomarker potential |
| gptkbp:is_studied_in |
pharmacology
cancer research |
| gptkbp:is_targeted_at |
gptkb:gene_therapy
clinical trials therapeutic agents small molecules antibody therapies |
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:promoter |
gptkb:MDM2
|
| gptkbp:promotes |
p53 degradation
|
| gptkbp:weight |
approximately 90 k Da
|
| gptkbp:bfsParent |
gptkb:CHK2
|
| gptkbp:bfsLayer |
6
|