|
gptkbp:instance_of
|
gptkb:protein
|
|
gptkbp:associated_with
|
gptkb:Cowden_syndrome
gptkb:disease
gptkb:chronic_myeloid_leukemia
gptkb:gastrointestinal_stromal_tumors
gptkb:myelodysplastic_syndromes
gptkb:neurofibromatosis_type_1
gptkb:hepatocellular_carcinoma
gptkb:familial_adenomatous_polyposis
gptkb:bile_duct_cancer
gptkb:Oncology
gptkb:Chondrichthyes
gptkb:Kaposi's_sarcoma
gptkb:neurofibromatosis_type_2
gptkb:pancreatic_cancer
gptkb:cervical_cancer
gptkb:Li-Fraumeni_syndrome
gptkb:Wilms_tumor
gptkb:neuroblastoma
gptkb:Peutz-Jeghers_syndrome
gptkb:Gardner_syndrome
gptkb:pheochromocytoma
ovarian cancer
endometrial cancer
liver cancer
oral cancer
esophageal cancer
bladder cancer
head and neck cancer
neuroendocrine tumors
aplastic anemia
thymoma
primary central nervous system lymphoma
germ cell tumors
tuberous sclerosis complex
adrenocortical carcinoma
poor prognosis in cancer patients
paraganglioma
|
|
gptkbp:clinical_trial
|
biomarker for cancer prognosis
|
|
gptkbp:discovered_by
|
David Beach
|
|
gptkbp:function
|
regulates cell cycle progression
|
|
gptkbp:genetic_studies
|
associated with cancer progression
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cyclin D1
|
|
gptkbp:initiated_by
|
CDK inhibitors
p Rb protein
p16 INK4a
p21 CIP1
|
|
gptkbp:interacts_with
|
gptkb:CDK6
CDK4
|
|
gptkbp:involved_in
|
DNA damage response
apoptosis regulation
cell differentiation
cell proliferation
tumorigenesis
|
|
gptkbp:is_expressed_in
|
regulated by transcription factors
upregulated in many cancers
|
|
gptkbp:is_recognized_as
|
human cells
|
|
gptkbp:location
|
gptkb:Atom
|
|
gptkbp:overexpression
|
leads to oncogenesis
|
|
gptkbp:pathway
|
MAPK pathway
Ras signaling pathway
PI3 K/ AKT pathway
|
|
gptkbp:promoter
|
CCND1
|
|
gptkbp:regulates
|
G1 phase of the cell cycle
|
|
gptkbp:role
|
cell cycle regulation
|
|
gptkbp:targets
|
gptkb:CDK4/6_inhibitors
|
|
gptkbp:type
|
gptkb:Cyclin-dependent_kinase
|
|
gptkbp:bfsParent
|
gptkb:CDK6
|
|
gptkbp:bfsLayer
|
7
|