|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:PI3K_pathway
gptkb:mTOR_pathway
|
|
gptkbp:alsoKnownAs
|
gptkb:ribosomal_protein_S6_kinase_beta-1
|
|
gptkbp:encodedBy
|
gptkb:RPS6KB1_gene
|
|
gptkbp:function
|
serine/threonine kinase
phosphorylates ribosomal protein S6
|
|
gptkbp:gene
|
gptkb:RPS6KB1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p70S6K
|
|
gptkbp:inhibitedBy
|
gptkb:rapamycin
|
|
gptkbp:involvedIn
|
cell proliferation
cell growth
protein synthesis
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
17q23.1
|
|
gptkbp:memberOf
|
gptkb:AGC_kinase_family
|
|
gptkbp:molecularWeight
|
70 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:phosphorylates
|
Ser371
Ser411
Ser424
Ser427
Thr389
|
|
gptkbp:regulates
|
translation initiation
cell size
|
|
gptkbp:significance
|
gptkb:cancer
insulin resistance
|
|
gptkbp:structure
|
contains kinase domain
contains autoinhibitory domain
|
|
gptkbp:UniProtID
|
P23443
|
|
gptkbp:bfsParent
|
gptkb:S6K
gptkb:S6K1
gptkb:AMPK_pathway
|
|
gptkbp:bfsLayer
|
6
|