|
gptkbp:instanceOf
|
gptkb:protein
gptkb:cyclin
|
|
gptkbp:alternativeName
|
gptkb:G2/mitotic-specific_cyclin-B1
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:degradationSignal
|
destruction box
|
|
gptkbp:degradedBy
|
gptkb:anaphase-promoting_complex
|
|
gptkbp:degradedDuring
|
anaphase
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodedBy
|
gptkb:CCNB1_gene
|
|
gptkbp:expressedIn
|
dividing cells
late S and G2 phases
|
|
gptkbp:formsComplexWith
|
gptkb:CDK1
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulation of cell cycle
activation of CDK1
|
|
gptkbp:GO
|
GO:0000086 (G2/M transition of mitotic cell cycle)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cyclin B1
|
|
gptkbp:inhibitedBy
|
gptkb:p21
gptkb:p53
|
|
gptkbp:interactsWith
|
gptkb:CDC25C
Wee1
|
|
gptkbp:involvedIn
|
G2/M transition
|
|
gptkbp:locatedOnChromosome
|
chromosome 5q13.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
48 kDa
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
|
|
gptkbp:overexpressedIn
|
various tumors
|
|
gptkbp:PDB
|
gptkb:2B9R
|
|
gptkbp:phosphorylates
|
gptkb:PLK1
Ser126
Ser133
Ser147
Thr161
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
mitosis
|
|
gptkbp:requires
|
entry into mitosis
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Molecular_Cell_Biology
|
|
gptkbp:subunit
|
Maturation Promoting Factor (MPF)
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P14635
|
|
gptkbp:usedAs
|
cell cycle marker
|
|
gptkbp:bfsParent
|
gptkb:CDK1_gene
gptkb:WAF1_gene
gptkb:CDK1
|
|
gptkbp:bfsLayer
|
6
|