|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:Apaf-1
gptkb:cytochrome_c
gptkb:apoptosome
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:catalyzes
|
cleavage of peptide bonds after aspartic acid residues
|
|
gptkbp:cleavage
|
procaspase-3
procaspase-7
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:EC_number
|
3.4.22.62
|
|
gptkbp:encodedBy
|
CASP9 gene
|
|
gptkbp:function
|
initiator caspase in apoptosis
|
|
gptkbp:gene
|
gptkb:CASP9
|
|
gptkbp:GO_term
|
GO:0006915 (apoptotic process)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Caspase-9
|
|
gptkbp:inhibitedBy
|
gptkb:Bcl-2
gptkb:XIAP
|
|
gptkbp:locatedIn
|
mitochondria
cytosol
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.21
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
1JXQ
|
|
gptkbp:relatedTo
|
gptkb:caspase_family
cell death
intrinsic apoptosis pathway
|
|
gptkbp:reviewedBy
|
gptkb:Nature
gptkb:Cell_Death_and_Differentiation
gptkb:Journal_of_Biological_Chemistry
|
|
gptkbp:structure
|
contains CARD domain
|
|
gptkbp:subunit
|
apoptosome complex
|
|
gptkbp:UniProtID
|
gptkb:P55211
|
|
gptkbp:bfsParent
|
gptkb:AKT1
|
|
gptkbp:bfsLayer
|
6
|