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gptkbp:instanceOf
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gptkb:protein
gptkb:enzyme
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gptkbp:abbreviation
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gptkb:PI3K
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gptkbp:activatedBy
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gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
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gptkbp:alsoKnownAs
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gptkb:CYP_family
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gptkbp:alternativeName
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gene_family
protein_domain
protein_family
Protein
Protein_Data_Bank_entry
Protein_structure
SNARE_protein
cytochrome_P450_family
fusion_protein
glycoprotein
phosphatidylinositol_3-kinase
phosphoinositide_3-kinase
protein_bar
protein_complex
protein_complex_subunit
protein_database
protein_isoform
protein_kinase
protein_motif
protein_phosphatase
protein_powder
protein_precursor
protein_sequence
protein_sequence_database
protein_structure
protein_subunit
protein_toxin
protein_variant
recombinant_protein
spike_protein
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gptkbp:associatedWith
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gptkb:cancer
gptkb:diabetes
gptkb:glioblastoma
colorectal cancer
inflammatory diseases
autoimmune disease
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gptkbp:catalyzes
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conversion of PIP2 to PIP3
phosphorylation of phosphatidylinositol at the 3-position
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gptkbp:cofactor
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hemoglobin
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gptkbp:contains
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gptkb:CYP11_family
gptkb:CYP17_family
gptkb:CYP19_family
gptkb:CYP1_family
gptkb:CYP21_family
gptkb:CYP24_family
gptkb:CYP27_family
gptkb:CYP2_family
gptkb:CYP3_family
gptkb:CYP46_family
gptkb:CYP4_family
gptkb:CYP51_family
gptkb:CYP5_family
gptkb:CYP7_family
gptkb:CYP8_family
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gptkbp:discoveredBy
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gptkb:Minor_J._Coon
gptkb:Lewis_Cantley
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gptkbp:discoveredIn
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1950s
1988
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gptkbp:EC_number
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2.7.1.153
1.14.-.-
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gptkbp:example
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gptkb:CYP1A2
gptkb:CYP2C9
gptkb:CYP2D6
gptkb:CYP3A4
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gptkbp:family
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phosphoinositide 3-kinases
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gptkbp:foundIn
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eukaryotes
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gptkbp:function
|
phosphorylates the 3' hydroxyl group of the inositol ring of phosphatidylinositol
synthesis of cholesterol
monooxygenase activity
drug metabolism
synthesis of steroids
synthesis of lipids
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gptkbp:gene
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gptkb:PIK3CA
gptkb:PIK3CB
gptkb:PIK3CD
gptkb:PIK3CG
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gptkbp:geneSymbolPrefix
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CYP
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gptkbp:GO_term
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gptkb:GO:0016303
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gptkbp:hasIsoform
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gptkb:class_III_PI3K
gptkb:class_II_PI3K
gptkb:class_I_PI3K
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https://www.w3.org/2000/01/rdf-schema#label
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protein
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gptkbp:inducedBy
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gptkb:rifampicin
phenobarbital
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gptkbp:inhibitedBy
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gptkb:milk
gptkb:LY294002
gptkb:wortmannin
azole antifungals
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gptkbp:involvedIn
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differentiation
survival
cell growth
motility
proliferation
intracellular trafficking
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gptkbp:involves
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gptkb:cancer
differentiation
survival
cell growth
motility
proliferation
intracellular trafficking
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gptkbp:locatedIn
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gptkb:cytoplasm
gptkb:plasma_membrane
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gptkbp:location
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gptkb:endoplasmic_reticulum
gptkb:cell_membrane
gptkb:cytoplasm
mitochondria
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gptkbp:numberOfFamiliesInHuman
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18
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gptkbp:numberOfGenes
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57
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gptkbp:numberOfSubfamiliesInHuman
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44
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gptkbp:pathway
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gptkb:PI3K/AKT/mTOR_pathway
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gptkbp:presentIn
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gptkb:Bacteria
animals
fungi
plants
archaea
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gptkbp:product
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phosphatidylinositol 3-phosphate
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gptkbp:regulates
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gptkb:AKT_signaling_pathway
gptkb:mTOR_pathway
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gptkbp:role
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signal transduction
DNA repair
metabolism
angiogenesis
cell migration
immune response
autophagy
apoptosis regulation
insulin signaling
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gptkbp:significance
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pharmacogenomics
drug interactions
adverse drug reactions
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gptkbp:substrate
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phosphatidylinositol
xenobiotics
endogenous compounds
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gptkbp:subunit
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p110 catalytic subunit
p85 regulatory subunit
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gptkbp:target
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PI3K inhibitors
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gptkbp:targetOfDrug
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gptkb:alpelisib
gptkb:copanlisib
gptkb:duvelisib
gptkb:idelalisib
umbraliserib
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gptkbp:type
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gptkb:Class_III_PI3K
gptkb:Class_II_PI3K
gptkb:Class_I_PI3K
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gptkbp:UniProtID
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gptkb:O00329_(PIK3CD)
P42336 (PIK3CA)
P42338 (PIK3CB)
P48736 (PIK3CG)
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gptkbp:bfsParent
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gptkb:meat
gptkb:milk
gptkb:seafood
gptkb:dish
gptkb:breakfast
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gptkbp:bfsLayer
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3
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