|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:PKB
gptkb:Protein_kinase_B_alpha
gptkb:RAC-alpha_serine/threonine-protein_kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
melanoma
prostate cancer
gastric cancer
|
|
gptkbp:discoveredBy
|
gptkb:Staal_et_al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:AKT1_protein
|
|
gptkbp:Entrez_Gene_ID
|
207
ENSG00000142208
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
regulation of cell survival
regulation of angiogenesis
regulation of cell growth
regulation of metabolism
|
|
gptkbp:HGNC_ID
|
391
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT1 gene
|
|
gptkbp:inhibitedBy
|
gptkb:PTEN
PHLPP
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_14
14q32.33
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Proteus_syndrome
|
|
gptkbp:OMIM
|
164730
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Akt1
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:phosphorylates
|
gptkb:PDK1
gptkb:mTORC2
|
|
gptkbp:proteinFamily
|
serine/threonine protein kinases
|
|
gptkbp:regulates
|
cell differentiation
transcription
cell migration
protein synthesis
glucose metabolism
cell cycle
|
|
gptkbp:target
|
AKT inhibitors
anticancer drugs
siRNA therapies
|
|
gptkbp:UniProtID
|
gptkb:P31749
|
|
gptkbp:bfsParent
|
gptkb:14q32.33_(AKT1)
gptkb:Akt_kinase
gptkb:V-akt_murine_thymoma_viral_oncogene_homolog_1
gptkb:PI3K-Akt_pathway
gptkb:Protein_kinase_B_alpha
gptkb:RAC-alpha_serine/threonine-protein_kinase
|
|
gptkbp:bfsLayer
|
7
|