Statements (35)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:signaling_molecule
|
| gptkbp:activatedBy |
gptkb:insulin
cytokines growth factors |
| gptkbp:downstreamOf |
gptkb:FOXO
gptkb:TSC2 gptkb:BAD gptkb:GSK3 gptkb:mTORC1 |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:cardiovascular_disease gptkb:diabetes |
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:has_upstream_activator |
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases |
| gptkbp:inhibitedBy |
PI3K inhibitors
mTOR inhibitors Akt inhibitors |
| gptkbp:involves |
gptkb:Akt
gptkb:PI3K gptkb:PDK1 gptkb:PTEN gptkb:mTOR |
| gptkbp:KEGGID |
hsa04151
|
| gptkbp:regulates |
cell proliferation
cell survival metabolism angiogenesis cell growth |
| gptkbp:studiedIn |
cancer research
cell biology metabolic disease research |
| gptkbp:bfsParent |
gptkb:UniProt:P01112
|
| gptkbp:bfsLayer |
5
|
| https://www.w3.org/2000/01/rdf-schema#label |
PI3K-Akt signaling pathway
|