Statements (39)
Predicate | Object |
---|---|
gptkbp:instanceOf |
signaling molecule
|
gptkbp:activatedBy |
gptkb:insulin
cytokines growth factors |
gptkbp:downstreamOf |
gptkb:FOXO
gptkb:TSC2 gptkb:BAD gptkb:GSK3 gptkb:mTORC1 |
gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:cardiovascular_disease gptkb:diabetes |
gptkbp:foundIn |
eukaryotic cells
|
gptkbp:has_upstream_activator |
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases |
https://www.w3.org/2000/01/rdf-schema#label |
PI3K-Akt signaling pathway
|
gptkbp:inhibitedBy |
PI3K inhibitors
mTOR inhibitors Akt inhibitors |
gptkbp:involves |
gptkb:Akt
gptkb:PI3K gptkb:PDK1 gptkb:PTEN gptkb:mTOR |
gptkbp:KEGGID |
hsa04151
|
gptkbp:regulates |
cell proliferation
cell survival metabolism angiogenesis cell growth |
gptkbp:studiedIn |
cancer research
cell biology metabolic disease research |
gptkbp:bfsParent |
gptkb:O00329_(PIK3CD)
gptkb:UniProt:P01112 gptkb:F-BVFA gptkb:PIK3CB gptkb:PIK3CD |
gptkbp:bfsLayer |
5
|