V-akt murine thymoma viral oncogene homolog 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:AKT1
gptkbp:associatedWith	gptkb:cancer gptkb:cardiovascular_disease gptkb:diabetes_mellitus prostate cancer
gptkbp:discoveredBy	gptkb:Staal_et_al.
gptkbp:discoveredIn	1991
gptkbp:domain	gptkb:PH_domain kinase domain
gptkbp:encodedBy	gptkb:AKT1_gene
gptkbp:Entrez_Gene_ID	ENSG00000142208
gptkbp:family	gptkb:AGC_kinase_family
gptkbp:function	serine/threonine kinase
gptkbp:gene	gptkb:AKT1
gptkbp:HGNC_ID	gptkb:HGNC:391
https://www.w3.org/2000/01/rdf-schema#label	V-akt murine thymoma viral oncogene homolog 1
gptkbp:involvedIn	gptkb:PI3K/AKT/mTOR_pathway cell proliferation cell survival cell growth glucose metabolism apoptosis regulation
gptkbp:locatedOnChromosome	14q32.33
gptkbp:molecularWeight	56 kDa
gptkbp:mutationAssociatedWith	drug resistance oncogenic activation
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologIn	mouse Akt1 rat Akt1
gptkbp:PDB	4EJN
gptkbp:phosphorylates	Ser473 Thr308
gptkbp:RefSeq	NM_005163
gptkbp:regulates	gptkb:BAD_protein gptkb:FOXO_transcription_factors gptkb:GSK3 gptkb:MDM2 gptkb:mTOR gptkb:p27_Kip1
gptkbp:target	gptkb:MK-2206 gptkb:capivasertib AKT inhibitors ipatasertib perifosine
gptkbp:UniProtID	gptkb:P31749
gptkbp:bfsParent	gptkb:AKT1
gptkbp:bfsLayer	6