Statements (42)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
gptkb:insulin
growth factors amino acids |
| gptkbp:component |
gptkb:mTORC1
gptkb:mTORC2 |
| gptkbp:downstream_effector |
gptkb:4EBP1
gptkb:S6K1 |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes aging neurodegenerative diseases |
| gptkbp:foundIn |
eukaryotic cells
|
| https://www.w3.org/2000/01/rdf-schema#label |
mTOR signaling pathway
|
| gptkbp:inhibitedBy |
gptkb:rapamycin
energy stress nutrient deprivation |
| gptkbp:involves |
gptkb:mTOR_protein
|
| gptkbp:location |
gptkb:lysosome
gptkb:cytoplasm |
| gptkbp:regulates |
cell proliferation
metabolism cell growth protein synthesis autophagy |
| gptkbp:target |
anticancer drugs
immunosuppressants |
| gptkbp:upstream_regulator |
gptkb:TSC1
gptkb:TSC2 gptkb:PI3K gptkb:AKT |
| gptkbp:bfsParent |
gptkb:4EBP1
gptkb:AKT1 gptkb:PI3KCA gptkb:PIK3CA_(p110α) gptkb:S6K1 gptkb:TSC1 gptkb:TSC2 gptkb:M6K gptkb:Rheb gptkb:mTOR |
| gptkbp:bfsLayer |
6
|