|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:GSK3B
GSK3-beta
glycogen synthase kinase 3 beta
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.26
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
pancreas
|
|
gptkbp:fullName
|
gptkb:Glycogen_synthase_kinase-3_beta
|
|
gptkbp:function
|
serine/threonine protein kinase
|
|
gptkbp:gene
|
gptkb:GSK3B
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GSK-3 beta
|
|
gptkbp:inhibitedBy
|
gptkb:Akt
gptkb:insulin
lithium
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
apoptosis
cell proliferation
neurogenesis
glycogen metabolism
insulin signaling pathway
|
|
gptkbp:locatedOnChromosome
|
3q13.33
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1Q4L
|
|
gptkbp:phosphorylates
|
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
Ser9
Tyr216
|
|
gptkbp:regulates
|
gptkb:synaptic_plasticity
apoptosis
cell differentiation
embryonic development
gene expression
metabolism
immune response
cell cycle
microtubule dynamics
neuronal survival
inflammatory response
circadian rhythm
|
|
gptkbp:structureType
|
monomer
|
|
gptkbp:UniProtID
|
gptkb:P49841
|
|
gptkbp:bfsParent
|
gptkb:AKT1
|
|
gptkbp:bfsLayer
|
6
|