|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase
gptkb:c-RAF
|
|
gptkbp:discoveredBy
|
H. H. Rapp et al.
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:encodes
|
gptkb:RAF1_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000132155
5894
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
signal transduction
serine/threonine-protein kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
9829
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAF1
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:AKT1
gptkb:MEK1
gptkb:MEK2
gptkb:PP2A
gptkb:RAS
gptkb:BRAF
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
cell differentiation
cell proliferation
apoptosis regulation
|
|
gptkbp:length
|
648
|
|
gptkbp:locatedOnChromosome
|
3p25
|
|
gptkbp:molecularWeight
|
73 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:LEOPARD_syndrome
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:OMIM
|
164760
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInFruitFly
|
gptkb:Raf
|
|
gptkbp:orthologInMouse
|
gptkb:Raf1
|
|
gptkbp:orthologInZebrafish
|
gptkb:raf1a
|
|
gptkbp:PDB
|
gptkb:3OMV
gptkb:4G0N
gptkb:6Q0J
|
|
gptkbp:phosphorylates
|
Ser259
Ser338
Ser621
|
|
gptkbp:regulates
|
phosphorylation
protein-protein interaction
ubiquitination
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:cytoplasm
mitochondria
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:HRAS
|
|
gptkbp:bfsLayer
|
5
|