|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:activatedBy
|
gptkb:insulin
cytokines
growth factors
|
|
gptkbp:AKT_activation_requires
|
phosphorylation at Ser473
phosphorylation at Thr308
|
|
gptkbp:AKT_binds
|
gptkb:PIP3
|
|
gptkbp:AKT_has
|
three isoforms
|
|
gptkbp:AKT_is_a
|
serine/threonine kinase
|
|
gptkbp:AKT_isoforms
|
gptkb:AKT1
gptkb:AKT2
gptkb:AKT3
|
|
gptkbp:alsoKnownAs
|
gptkb:PI3K/AKT_pathway
|
|
gptkbp:downstreamOf
|
gptkb:PI3K
gptkb:mTOR_pathway
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
cardiovascular diseases
|
|
gptkbp:firstDescribed
|
1990s
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AKT pathway
|
|
gptkbp:inhibitedBy
|
gptkb:PTEN
phosphatases
|
|
gptkbp:involves
|
gptkb:PI3K
gptkb:AKT
gptkb:PDK1
gptkb:PTEN
gptkb:mTOR
|
|
gptkbp:namedAfter
|
gptkb:AKT_oncogene
|
|
gptkbp:phosphorylates
|
gptkb:FOXO
gptkb:TSC2
gptkb:BAD
gptkb:GSK3
gptkb:MDM2
gptkb:mTORC1
|
|
gptkbp:PI3K_converts
|
PIP2 to PIP3
|
|
gptkbp:PI3K/AKT_pathway
|
is conserved in eukaryotes
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell survival
metabolism
angiogenesis
cell growth
cell migration
|
|
gptkbp:target
|
AKT inhibitors
PI3K inhibitors
anticancer drugs
mTOR inhibitors
|
|
gptkbp:bfsParent
|
gptkb:PI3K
|
|
gptkbp:bfsLayer
|
5
|