|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:3-phosphoinositide-dependent_protein_kinase-1
gptkb:PDPK1
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
gptkb:PDPK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
5170
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:fullName
|
gptkb:3-phosphoinositide-dependent_protein_kinase-1
|
|
gptkbp:function
|
activates AGC family kinases
serine/threonine kinase
|
|
gptkbp:gene
|
gptkb:PDPK1
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:8816
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDK1
|
|
gptkbp:inhibitedBy
|
gptkb:BX-795
gptkb:GSK2334470
|
|
gptkbp:interactsWith
|
gptkb:AKT2
gptkb:AKT3
gptkb:PDK2
gptkb:PI3K
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT_signaling_pathway
cell survival
cell growth regulation
metabolism regulation
|
|
gptkbp:locatedOnChromosome
|
16p13.3
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
63 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1H1W
gptkb:1UU3
2BIY
|
|
gptkbp:phosphorylates
|
gptkb:AKT1
gptkb:S6K
gptkb:SGK
gptkb:PKC
|
|
gptkbp:regulates
|
activated by PIP3
regulated by phosphorylation
|
|
gptkbp:reviewedBy
|
gptkb:Cell_Signaling_Technology
gptkb:Nature
gptkb:UniProt
|
|
gptkbp:structure
|
contains PH domain
contains kinase domain
|
|
gptkbp:UniProtID
|
gptkb:O15530
|
|
gptkbp:bfsParent
|
gptkb:PI3K/AKT/mTOR_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:bfsLayer
|
5
|