|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:CDKN1B
cyclin-dependent kinase inhibitor 1B
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:binds
|
cyclin D-CDK4 complex
cyclin E-CDK2 complex
|
|
gptkbp:degradationPathway
|
gptkb:proteasome
|
|
gptkbp:degradedBy
|
gptkb:SCF(SKP2)_complex
|
|
gptkbp:discoveredBy
|
gptkb:Polyak_et_al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:downregulatedIn
|
various cancers
|
|
gptkbp:encodedBy
|
gptkb:CDKN1B_gene
|
|
gptkbp:function
|
cyclin-dependent kinase inhibitor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p27 Kip1
|
|
gptkbp:inhibitedBy
|
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:involvedIn
|
apoptosis
cellular senescence
contact inhibition
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:12p13
|
|
gptkbp:molecularWeight
|
27 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:multiple_endocrine_neoplasia_type_4
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1JSU
|
|
gptkbp:phosphorylates
|
gptkb:SRC
gptkb:AKT
gptkb:CDK2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:TGF-beta
cell proliferation
cell cycle
G1 phase of cell cycle
mitogenic signals
|
|
gptkbp:role
|
tumor suppression
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:UniProtID
|
P46527
|
|
gptkbp:bfsParent
|
gptkb:AKT1
|
|
gptkbp:bfsLayer
|
6
|