|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:affects
|
midazolam metabolism
statin metabolism
tacrolimus metabolism
|
|
gptkbp:chromosomeArm
|
7q22.1
|
|
gptkbp:encodes
|
gptkb:Cytochrome_P450_3A5
|
|
gptkbp:Entrez_Gene_ID
|
1577
ENSG00000106344
|
|
gptkbp:expressedIn
|
gptkb:adrenal_gland
gptkb:kidney
liver
intestine
|
|
gptkbp:hasBiologicalActivity
|
monooxygenase activity
oxidoreductase activity
|
|
gptkbp:hasPolymorphism
|
CYP3A5*1
CYP3A5*3
|
|
gptkbp:HGNC_ID
|
2596
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP3A5
|
|
gptkbp:inhibitedBy
|
gptkb:alectinib
gptkb:brigatinib
gptkb:ceritinib
gptkb:crizotinib
gptkb:lorlatinib
gptkb:erlotinib
gptkb:gefitinib
gptkb:milk
gptkb:fluvoxamine
gptkb:cyclosporine
gptkb:voriconazole
gptkb:dasatinib
gptkb:cobicistat
gptkb:fluconazole
gptkb:omeprazole
gptkb:clarithromycin
gptkb:ritonavir
gptkb:sorafenib
gptkb:erythromycin
gptkb:ketoconazole
gptkb:verapamil
gptkb:cabozantinib
gptkb:vandetanib
gptkb:imatinib
gptkb:pazopanib
gptkb:sunitinib
gptkb:lapatinib
gptkb:fluoxetine
gptkb:aprepitant
gptkb:boceprevir
gptkb:nilotinib
gptkb:nefazodone
gptkb:dronedarone
gptkb:miconazole
gptkb:telithromycin
gptkb:ticlopidine
cimetidine
quercetin
resveratrol
amiodarone
curcumin
diltiazem
indinavir
itraconazole
nicardipine
posaconazole
saquinavir
troleandomycin
danazol
|
|
gptkbp:involvedIn
|
drug metabolism
xenobiotic metabolism
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:OMIM
|
605724
|
|
gptkbp:orthologInMouse
|
Cyp3a11
|
|
gptkbp:regulates
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:dexamethasone
gptkb:carbamazepine
gptkb:St._John's_Wort
gptkb:constitutive_androstane_receptor
gptkb:pregnane_X_receptor
phenobarbital
glucocorticoid receptor
|
|
gptkbp:substrate
|
gptkb:progesterone
gptkb:dextromethorphan
gptkb:cyclosporine
gptkb:nifedipine
gptkb:omeprazole
gptkb:lidocaine
gptkb:atorvastatin
gptkb:clarithromycin
gptkb:ritonavir
gptkb:aflatoxin_B1
gptkb:tamoxifen
gptkb:estradiol
gptkb:carbamazepine
gptkb:erythromycin
gptkb:verapamil
gptkb:ifosfamide
gptkb:vincristine
gptkb:lovastatin
gptkb:simvastatin
gptkb:fexofenadine
quinidine
cortisol
antineoplastic agent
docetaxel
indinavir
paclitaxel
saquinavir
alprazolam
testosterone
carcinogens
|
|
gptkbp:UniProtID
|
P20815
|
|
gptkbp:bfsParent
|
gptkb:CYP3_family
|
|
gptkbp:bfsLayer
|
5
|